Alexander A Soukas
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Explore the profile of Alexander A Soukas including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
3197
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Recent Articles
1.
Zhou Y, Ahsan F, Soukas A
bioRxiv
. 2025 Mar;
PMID: 40027662
As the only gateway governing nucleocytoplasmic transport, the nuclear pore complex (NPC) maintains fundamental cellular processes and deteriorates with age. However, the study of age-related roles of single NPC components...
2.
Yao L, Wang L, Zhang R, Soukas A, Wu L
Trends Endocrinol Metab
. 2024 Sep;
PMID: 39227192
Metformin, an oral antihyperglycemic drug that has been in use for over 60 years, remains a first-line therapy for type 2 diabetes (T2D). Numerous studies have suggested that metformin promotes...
3.
Wronski M, Plessow F, Kerem L, Asanza E, ODonoghue M, Stanford F, et al.
Contemp Clin Trials
. 2024 Mar;
140:107511.
PMID: 38522969
No abstract available.
4.
Emans S, Yerevanian A, Ahsan F, Rotti J, Zhou Y, Cedillo L, et al.
Development
. 2023 Nov;
150(24).
PMID: 37982457
Both hedgehog (Hh) and target of rapamycin complex 2 (TORC2) are central, evolutionarily conserved signaling pathways that regulate development and metabolism. In C. elegans, loss of the essential TORC2 component...
5.
Liu H, Yerevanian A, Westerhoff M, Hastings M, Guerra J, Zhao M, et al.
Diabetes
. 2023 Nov;
73(2):260-279.
PMID: 37934943
Article Highlights:
6.
Cedillo L, Ahsan F, Li S, Stuhr N, Zhou Y, Zhang Y, et al.
Elife
. 2023 Aug;
12.
PMID: 37606250
Biguanides, including the world's most prescribed drug for type 2 diabetes, metformin, not only lower blood sugar, but also promote longevity in preclinical models. Epidemiologic studies in humans parallel these...
7.
Bernardi P, Gerle C, Halestrap A, Jonas E, Karch J, Mnatsakanyan N, et al.
Cell Death Differ
. 2023 Jul;
30(8):1869-1885.
PMID: 37460667
The mitochondrial permeability transition (mPT) describes a Ca-dependent and cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that allows diffusion of molecules up to 1.5 kDa in size. It...
8.
Yerevanian A, Murphy L, Emans S, Zhou Y, Ahsan F, Baker D, et al.
Aging Cell
. 2022 Oct;
21(11):e13718.
PMID: 36181246
Riboflavin is an essential cofactor in many enzymatic processes and in the production of flavin adenine dinucleotide (FAD). Here, we report that the partial depletion of riboflavin through knockdown of...
9.
Wronski M, Plessow F, Kerem L, Asanza E, ODonoghue M, Stanford F, et al.
Contemp Clin Trials
. 2022 Sep;
122:106909.
PMID: 36087842
Background: Obesity affects more than one-third of adults in the U.S., and effective treatment options are urgently needed. Oxytocin administration induces weight loss in animal models of obesity via effects...
10.
Zhou B, Zhang Y, Li S, Wu L, Fejes-Toth G, Naray-Fejes-Toth A, et al.
Cell Rep
. 2021 Oct;
37(1):109785.
PMID: 34610303
A hallmark of type 2 diabetes (T2D) is hepatic resistance to insulin's glucose-lowering effects. The serum- and glucocorticoid-regulated family of protein kinases (SGK) is activated downstream of mechanistic target of...