Alexa K Dowdell
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Explore the profile of Alexa K Dowdell including associated specialties, affiliations and a list of published articles.
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10
Citations
44
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Recent Articles
1.
Dowdell A, Meng R, Vita A, Bapat B, Hanes D, Chang S, et al.
JCO Oncol Pract
. 2024 Nov;
20(11):1523-1532.
PMID: 39531849
Purpose: Precision therapies and immunotherapies have revolutionized cancer care, with novel genomic biomarker-associated therapies being introduced into clinical practice rapidly, resulting in notable gains in patient survival. Despite this, there...
2.
Kramer G, Blair T, Bambina S, Kaur A, Alice A, Baird J, et al.
Sci Rep
. 2024 May;
14(1):11909.
PMID: 38789721
T cells recirculate through tissues and lymphatic organs to scan for their cognate antigen. Radiation therapy provides site-specific cytotoxicity to kill cancer cells but also has the potential to eliminate...
3.
Schmauch E, Piening B, Mohebnasab M, Xia B, Zhu C, Stern J, et al.
Nat Med
. 2024 May;
30(5):1448-1460.
PMID: 38760586
In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand the detailed...
4.
Kaplan H, Dowdell A, Berry A, Shimol R, Robinson F, Carney C, et al.
Breast Cancer Res Treat
. 2024 Mar;
205(3):451-464.
PMID: 38523186
Purpose: The progression of ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) in humans is highly variable. To better understand the relationship between them, we performed a multi-omic...
5.
Alsulaiman R, Al-Quorain A, Al-Muhanna F, Piotrowski S, Kurdi E, Vatte C, et al.
BMC Gastroenterol
. 2023 Jul;
23(1):258.
PMID: 37507685
Background: Crohn's diseases and ulcerative colitis, both of which are chronic immune-mediated disorders of the gastrointestinal tract are major contributors to the overarching Inflammatory bowel diseases. It has become increasingly...
6.
Medler T, Blair T, Alice A, Dowdell A, Piening B, Crittenden M, et al.
Sci Rep
. 2023 May;
13(1):8634.
PMID: 37244938
Radiation therapy induces immunogenic cell death in cancer cells, whereby released endogenous adjuvants are sensed by immune cells to direct adaptive immune responses. TLRs expressed on several immune subtypes recognize...
7.
Al-Muhanna F, Dowdell A, Al Eleq A, Albaker W, Brooks A, Al-Sultan A, et al.
BMC Microbiol
. 2022 Dec;
22(1):301.
PMID: 36510121
Background: Large-scale gut microbiome sequencing has revealed key links between microbiome dysfunction and metabolic diseases such as type 2 diabetes (T2D). To date, these efforts have largely focused on Western...
8.
Blair T, Bambina S, Kramer G, Dowdell A, Alice A, Baird J, et al.
Life Sci Alliance
. 2022 Apr;
5(9).
PMID: 35487695
Radiation therapy generates extensive cancer cell death capable of promoting tumor-specific immunity. Within the tumor, conventional dendritic cells (cDCs) are known to carry tumor-associated antigens to the draining lymph node...
9.
Piening B, Dowdell A, Zhang M, Loza B, Walls D, Gao H, et al.
J Heart Lung Transplant
. 2022 Mar;
41(6):840-848.
PMID: 35317953
Background: Heart transplantation provides a significant improvement in survival and quality of life for patients with end-stage heart disease, however many recipients experience different levels of graft rejection that can...
10.
Peterson T, Lechtenberg K, Piening B, Lucas T, Wei E, Chaib H, et al.
Transl Stroke Res
. 2020 Jun;
12(2):331-346.
PMID: 32588199
Obesity is associated with chronic peripheral inflammation, is a risk factor for stroke, and causes increased infarct sizes. To characterize how obesity increases infarct size, we fed a high-fat diet...