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Alexa E Horner

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Articles 11
Citations 600
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Recent Articles
1.
Montalban-Loro R, Lassi G, Lozano-Urena A, Perez-Villalba A, Jimenez-Villalba E, Charalambous M, et al.
Proc Natl Acad Sci U S A . 2021 Mar; 118(11). PMID: 33712542
Neurogenesis in the adult brain gives rise to functional neurons, which integrate into neuronal circuits and modulate neural plasticity. Sustained neurogenesis throughout life occurs in the subgranular zone (SGZ) of...
2.
Borrie S, Horner A, Yoshimura A, Legius E, Kopanitsa M, Brems H
Genes Brain Behav . 2021 Feb; 20(5):e12727. PMID: 33624414
RASopathies are neuro-cardio-facio-cutaneous disorders stemming from mutations in genes regulating the RAS-MAPK pathway. Legius syndrome is a rare RASopathy disorder caused by mutations in the SPRED1 gene. SPRED1 protein negatively...
3.
Horner A, Norris R, McLaren-Jones R, Alexander L, Komiyama N, Grant S, et al.
Genes Brain Behav . 2020 Dec; 20(1):e12723. PMID: 33347690
The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved multiprotein complex that comprises neurotransmitter receptors, cell-adhesion molecules, scaffold proteins and enzymes, which are essential for brain signalling and...
4.
Horner A, Mclaughlin C, Afinowi N, Bussey T, Saksida L, Komiyama N, et al.
Eur J Neurosci . 2017 Dec; 47(2):164-176. PMID: 29237242
PSD-95 is one of the most abundant proteins of the postsynaptic density of excitatory synapses. It functions as the backbone of protein supercomplexes that mediate signalling between membrane glutamate receptors...
5.
Benevento M, Oomen C, Horner A, Amiri H, Jacobs T, Pauwels C, et al.
Sci Rep . 2017 Jan; 7:40284. PMID: 28071689
Heterozygous mutations or deletions of the human Euchromatin Histone Methyltransferase 1 (EHMT1) gene are the main causes of Kleefstra syndrome, a neurodevelopmental disorder that is characterized by impaired memory, autistic...
6.
Kim C, Heath C, Kent B, Horner A, Bussey T, Saksida L
Psychopharmacology (Berl) . 2015 Jul; 232(24):4537. PMID: 26206382
No abstract available.
7.
Oomen C, Hvoslef-Eide M, Heath C, Mar A, Horner A, Bussey T, et al.
Nat Protoc . 2013 Sep; 8(10):2006-21. PMID: 24051961
The automated touchscreen operant chamber for rats and mice allows for the assessment of multiple cognitive domains within the same testing environment. This protocol presents the location discrimination (LD) task...
8.
Mar A, Horner A, Nilsson S, Alsio J, Kent B, Kim C, et al.
Nat Protoc . 2013 Sep; 8(10):1985-2005. PMID: 24051960
This protocol details a subset of assays developed within the touchscreen platform to measure various aspects of executive function in rodents. Three main procedures are included: extinction, measuring the rate...
9.
Horner A, Heath C, Hvoslef-Eide M, Kent B, Kim C, Nilsson S, et al.
Nat Protoc . 2013 Sep; 8(10):1961-84. PMID: 24051959
An increasingly popular method of assessing cognitive functions in rodents is the automated touchscreen platform, on which a number of different cognitive tests can be run in a manner very...
10.
Romberg C, Yang S, Melani R, Andrews M, Horner A, Spillantini M, et al.
J Neurosci . 2013 Apr; 33(16):7057-65. PMID: 23595763
Perineuronal nets (PNNs) are extracellular matrix structures surrounding cortical neuronal cell bodies and proximal dendrites and are involved in the control of brain plasticity and the closure of critical periods....