Alexa Childs
Overview
Explore the profile of Alexa Childs including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
157
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0
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Recent Articles
1.
Childs A, Aidoo-Micah G, Maini M, Meyer T
JHEP Rep
. 2024 Sep;
6(10):101130.
PMID: 39308986
Hepatocellular carcinoma (HCC) is a major global healthcare challenge, with >1 million patients predicted to be affected annually by 2025. In contrast to other cancers, both incidence and mortality rates...
2.
Childs A, Gerrand C, Brennan B, Young R, Rankin K, Parry M, et al.
Cancers (Basel)
. 2024 Jul;
16(13).
PMID: 39001413
There has been little change to the standard treatment for osteosarcoma (OS) over the last 25 years and there is an unmet need to identify new biomarkers and novel therapeutic...
3.
Vesely C, Wong Y, Childs A, Akarca A, Dhami P, Vaikkinen H, et al.
Clin Cancer Res
. 2022 Mar;
28(12):2657-2668.
PMID: 35320356
Purpose: The immune tumor microenvironment and the potential therapeutic opportunities for immunotherapy in small intestinal neuroendocrine tumors (siNET) have not been fully defined. Experimental Design: Herein, we studied 40 patients...
4.
Childs A, Zakeri N, Ma Y, ORourke J, Ross P, Hashem E, et al.
Br J Cancer
. 2021 Sep;
125(10):1350-1355.
PMID: 34526664
Background: Advanced hepatocellular carcinoma (HCC) is commonly diagnosed using non-invasive radiological criteria (NIRC) defined by the European Association for the Study of the Liver or the American Association for the...
5.
Childs A, Steele C, Vesely C, Rizzo F, Ensell L, Lowe H, et al.
Endocr Relat Cancer
. 2021 Jul;
28(9):631-644.
PMID: 34280125
Single-cell profiling of circulating tumor cells (CTCs) as part of a minimally invasive liquid biopsy presents an opportunity to characterize and monitor tumor heterogeneity and evolution in individual patients. In...
6.
Frizziero M, Wang X, Chakrabarty B, Childs A, Luong T, Walter T, et al.
World J Gastroenterol
. 2019 Oct;
25(39):5991-6005.
PMID: 31660035
Background: Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare diagnosis, mainly encountered in the gastro-entero-pancreatic tract. There is limited knowledge of its epidemiology, prognosis and biology, and the best management...
7.
Rizzo F, Vesely C, Childs A, Marafioti T, Khan M, Mandair D, et al.
Br J Cancer
. 2019 Jan;
120(3):294-300.
PMID: 30636773
Background: Bone metastases are associated with a worse outcome in patients with neuroendocrine tumours (NETs). Tumour overexpression of C-X-C chemokine receptor 4 (CXCR4) appears predictive of skeletal involvement. We investigated...
8.
Wicki A, Brown N, Xyrafas A, Bize V, Hawle H, Berardi S, et al.
Eur J Cancer
. 2018 Apr;
96:6-16.
PMID: 29660598
Background: PQR309 is an orally bioavailable, balanced pan-phosphatidylinositol-3-kinase (PI3K), mammalian target of rapamycin (mTOR) C1 and mTORC2 inhibitor. Patients And Methods: This is an accelerated titration, 3 + 3 dose-escalation,...
9.
Lamarca A, Walter T, Pavel M, Borbath I, Freis P, Nunez B, et al.
J Natl Cancer Inst
. 2017 Jan;
109(5).
PMID: 28130474
Background: Prognostic markers for risk stratification of patients with gastrointestinal high-grade neuroendocrine carcinomas (GI-NECs) are lacking; we designed and validated a prognostic score for overall survival (OS). Methods: Consecutive patients...
10.
Childs A, Vesely C, Ensell L, Lowe H, Luong T, Caplin M, et al.
Br J Cancer
. 2016 Nov;
115(12):1540-1547.
PMID: 27875519
Background: Neuroendocrine tumours (NET) overexpress somatostatin receptors (SSTR) that can be targeted for therapy. Somatostatin receptor expression is routinely measured by molecular imaging but the resolution is insufficient to define...