Alex Zelter
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Explore the profile of Alex Zelter including associated specialties, affiliations and a list of published articles.
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42
Citations
2197
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Recent Articles
1.
Riffle M, Zelter A, Jaschob D, Hoopmann M, Faivre D, Moritz R, et al.
J Proteome Res
. 2025 Mar;
PMID: 40036265
Liquid chromatography-tandem mass spectrometry employing data-dependent acquisition (DDA) is a mature, widely used proteomics technique routinely applied to proteome profiling, protein-protein interaction studies, biomarker discovery, and protein modification analysis. Numerous...
2.
Miedlar E, Hamilton G, Witus S, Gonske S, Riffle M, Zelter A, et al.
bioRxiv
. 2024 Nov;
PMID: 39605442
Previously, we reconstituted a minimal functional kinetochore from recombinant proteins that was capable of transmitting force from dynamic microtubules to nucleosomes containing the centromere-specific histone variant Cse4 (Hamilton et al....
3.
Zelter A, Riffle M, Shteynberg D, Zhong G, Riddle E, Hoopmann M, et al.
J Proteome Res
. 2024 Oct;
23(11):5143-5152.
PMID: 39442081
Covalent protein adducts formed by drugs or their reactive metabolites are risk factors for adverse reactions, and inactivation of cytochrome P450 (CYP) enzymes. Characterization of drug-protein adducts is limited due...
4.
Vicente J, Wagenbach M, Decarreau J, Zelter A, MacCoss M, Davis T, et al.
bioRxiv
. 2024 Apr;
PMID: 38617353
Centrosomes are the principal microtubule-organizing centers of the cell and play an essential role in mitotic spindle function. Centrosome biogenesis is achieved by strict control of protein acquisition and phosphorylation...
5.
Witus S, Tuttle L, Li W, Zelter A, Wang M, Kermoade K, et al.
EMBO J
. 2023 Jun;
42(15):e113565.
PMID: 37305927
BRCA1/BARD1 is a tumor suppressor E3 ubiquitin (Ub) ligase with roles in DNA damage repair and in transcriptional regulation. BRCA1/BARD1 RING domains interact with nucleosomes to facilitate mono-ubiquitylation of distinct...
6.
Haase M, Olafsson G, Flores R, Boakye-Ansah E, Zelter A, Dickinson M, et al.
EMBO J
. 2023 Jan;
42(8):e112600.
PMID: 36651597
Forcing budding yeast to chromatinize their DNA with human histones manifests an abrupt fitness cost. We previously proposed chromosomal aneuploidy and missense mutations as two potential modes of adaptation to...
7.
Hoopmann M, Shteynberg D, Zelter A, Riffle M, Lyon A, Agard D, et al.
J Proteome Res
. 2023 Jan;
22(2):647-655.
PMID: 36629399
Fragmentation ion spectral analysis of chemically cross-linked proteins is an established technology in the proteomics research repertoire for determining protein interactions, spatial orientation, and structure. Here we present Kojak version...
8.
Reiter K, Zelter A, Janowska M, Riffle M, Shulman N, MacLean B, et al.
Structure
. 2022 Jun;
30(9):1269-1284.e6.
PMID: 35716664
RING-between-RING (RBR) E3 ligases mediate ubiquitin transfer through an obligate E3-ubiquitin thioester intermediate prior to substrate ubiquitination. Although RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic, and...
9.
Flores R, Peterson Z, Zelter A, Riffle M, Asbury C, Davis T
J Cell Biol
. 2022 Mar;
221(5).
PMID: 35353161
Accurate mitosis requires kinetochores to make persistent, load-bearing attachments to dynamic microtubule tips, thereby coupling chromosome movements to tip growth and shortening. This tip-coupling behavior depends on the conserved Ndc80...
10.
Riffle M, Hoopmann M, Jaschob D, Zhong G, Moritz R, MacCoss M, et al.
Anal Chem
. 2022 Feb;
94(8):3501-3509.
PMID: 35184559
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life-threatening adverse drug reactions. The masses of reactive metabolites...