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Alex Rialdi

Explore the profile of Alex Rialdi including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 121
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Recent Articles
1.
Lehrich B, Monga S, Lehrich B, Delgado E, Yasaka T, Delgado E, et al.
Res Sq . 2024 Dec; PMID: 39711542
First-line immune checkpoint inhibitor (ICI) combinations show responses in subsets of hepatocellular carcinoma (HCC) patients. Nearly half of HCCs are Wnt-active with mutations in (encoding for β-catenin), , or ,...
2.
Rialdi A, Duffy M, Scopton A, Fonseca F, Zhao J, Schwarz M, et al.
Nat Cancer . 2023 Aug; 4(8):1157-1175. PMID: 37537299
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. β-Catenin (CTNNB1)-mutated HCC represents 30% of cases of the disease with no precision therapeutics available. Using chemical libraries derived...
3.
Abril-Fornaguera J, Torrens L, Andreu-Oller C, Carrillo-Reixach J, Rialdi A, Balaseviciute U, et al.
Mol Cancer Ther . 2023 Feb; 22(4):485-498. PMID: 36780225
Management of hepatoblastoma (HB), the most frequent pediatric liver cancer, is based on surgical resection and perioperative chemotherapy regimens. In this study, we aimed to identify actionable targets in HB...
4.
Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, et al.
Nat Struct Mol Biol . 2018 Sep; 25(9):885-893. PMID: 30177761
Viral infection perturbs host cells and can be used to uncover regulatory mechanisms controlling cellular responses and susceptibility to infections. Using cell biological, biochemical, and genetic tools, we reveal that...
5.
Rialdi A, Campisi L, Zhao N, Lagda A, Pietzsch C, Ho J, et al.
Science . 2016 Apr; 352(6289):aad7993. PMID: 27127234
The host innate immune response is the first line of defense against pathogens and is orchestrated by the concerted expression of genes induced by microbial stimuli. Deregulated expression of these...