Alex Muthengi
Overview
Explore the profile of Alex Muthengi including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
9
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0
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Recent Articles
1.
Muthengi A, Wimalasena V, Yosief H, Bikowitz M, Sigua L, Wang T, et al.
J Med Chem
. 2021 Apr;
64(9):5787-5801.
PMID: 33872011
The use of epigenetic bromodomain inhibitors as anticancer therapeutics has transitioned from targeting bromodomain extraterminal domain (BET) proteins into targeting non-BET bromodomains. The two most relevant non-BET bromodomain oncology targets...
2.
Muthengi A, Erickson J, Muriph R, Zhang W
J Org Chem
. 2019 Apr;
84(9):5927-5935.
PMID: 30932493
A reaction sequence involving three-component [3 + 2] cycloaddition of azomethine ylides followed by CuI-catalyzed cascade trifluoromethyl radical addition and cyclization is developed for diastereoselective synthesis of fused-tetrahydrobenzodiazepin-3-ones.
3.
Zhang X, Pham K, Liu S, Legris M, Muthengi A, Jasinski J, et al.
Beilstein J Org Chem
. 2016 Nov;
12:2204-2210.
PMID: 27829928
The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino...