Alex Meissner
Overview
Explore the profile of Alex Meissner including associated specialties, affiliations and a list of published articles.
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12
Citations
5132
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Recent Articles
1.
Nehme R, Zuccaro E, Ghosh S, Li C, Sherwood J, Pietilainen O, et al.
Cell Rep
. 2018 May;
23(8):2509-2523.
PMID: 29791859
Transcription factor programming of pluripotent stem cells (PSCs) has emerged as an approach to generate human neurons for disease modeling. However, programming schemes produce a variety of cell types, and...
2.
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
De Jager P, Srivastava G, Lunnon K, Burgess J, Schalkwyk L, Yu L, et al.
Nat Neurosci
. 2014 Aug;
17(9):1156-63.
PMID: 25129075
We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level...
3.
Zacharek S, Fillmore C, Lau A, Gludish D, Chou A, Ho J, et al.
Cell Stem Cell
. 2011 Sep;
9(3):272-81.
PMID: 21885022
BMI1 is required for the self-renewal of stem cells in many tissues including the lung epithelial stem cells, Bronchioalveolar Stem Cells (BASCs). Imprinted genes, which exhibit expression from only the...
4.
Wirt S, Adler A, Gebala V, Weimann J, Schaffer B, Saddic L, et al.
J Cell Biol
. 2010 Nov;
191(4):809-25.
PMID: 21059851
The ability of progenitor cells to exit the cell cycle is essential for proper embryonic development and homeostasis, but the mechanisms governing cell cycle exit are still not fully understood....
5.
Amit I, Garber M, Chevrier N, Leite A, Donner Y, Eisenhaure T, et al.
Science
. 2009 Sep;
326(5950):257-63.
PMID: 19729616
Models of mammalian regulatory networks controlling gene expression have been inferred from genomic data but have largely not been validated. We present an unbiased strategy to systematically perturb candidate regulators...
6.
Daley G, Lensch M, Jaenisch R, Meissner A, Plath K, Yamanaka S
Cell Stem Cell
. 2009 Mar;
4(3):200-1.
PMID: 19265657
No abstract available.
7.
Ventura A, Young A, Winslow M, Lintault L, Meissner A, Erkeland S, et al.
Cell
. 2008 Mar;
132(5):875-86.
PMID: 18329372
miR-17 approximately 92, miR-106b approximately 25, and miR-106a approximately 363 belong to a family of highly conserved miRNA clusters. Amplification and overexpression of miR-1792 is observed in human cancers, and...
8.
Linhart H, Lin H, Yamada Y, Moran E, Steine E, Gokhale S, et al.
Genes Dev
. 2007 Dec;
21(23):3110-22.
PMID: 18056424
Increased methylation of CpG islands and silencing of affected target genes is frequently found in human cancer; however, in vivo the question of causality has only been addressed by loss-of-function...
9.
Blelloch R, Wang Z, Meissner A, Pollard S, Smith A, Jaenisch R
Stem Cells
. 2006 May;
24(9):2007-13.
PMID: 16709876
Reprogramming of a differentiated cell nucleus by somatic cell nuclear transplantation is an inefficient process. Following nuclear transfer, the donor nucleus often fails to express early embryonic genes and establish...
10.
Bernstein B, Mikkelsen T, Xie X, Kamal M, Huebert D, Cuff J, et al.
Cell
. 2006 Apr;
125(2):315-26.
PMID: 16630819
The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests that HCNE-rich regions may contain key...