Alex Farfel
Overview
Explore the profile of Alex Farfel including associated specialties, affiliations and a list of published articles.
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5
Citations
7
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Recent Articles
1.
Ciavattone N, Bevoor A, Farfel A, Rehman A, Ho K, Rock E, et al.
Sci Rep
. 2025 Feb;
15(1):5204.
PMID: 39939722
Patients with triple negative breast cancer (TNBC) show only modest response rates to immune checkpoint inhibitor immunotherapy, motivating ongoing efforts to identify approaches to boost efficacy. Using an immunocompetent mouse...
2.
Ciavattone N, Guan N, Farfel A, Stauff J, Desmond T, Viglianti B, et al.
JCI Insight
. 2024 Mar;
9(8).
PMID: 38502228
Evaluating the response to immune checkpoint inhibitors (ICIs) remains an unmet challenge in triple-negative breast cancer (TNBC). The requirement for cholesterol in the activation and function of T cells led...
3.
Sinha S, Farfel A, Luker K, Parker B, Yeung K, Luker G, et al.
PNAS Nexus
. 2024 Feb;
3(2):pgae014.
PMID: 38312224
Self-sufficiency (autonomy) in growth signaling, the earliest recognized hallmark of cancer, is fueled by the tumor cell's ability to "secrete-and-sense" growth factors (GFs); this translates into cell survival and proliferation...
4.
Ciavattone N, Guan J, Farfel A, Desmond T, Viglianti B, Scott P, et al.
bioRxiv
. 2023 Oct;
PMID: 37873149
Predicting the response to cancer immunotherapy remains an unmet challenge in triple-negative breast cancer (TNBC) and other malignancies. T cells, the major target of current checkpoint inhibitor immunotherapies, accumulate cholesterol...
5.
Humphries B, Zhang A, Buschhaus J, Bevoor A, Farfel A, Rajendran S, et al.
iScience
. 2023 May;
26(6):106788.
PMID: 37235049
Mitochondria produce reactive oxygen species (ROS), which function in signal transduction. Mitochondrial dynamics, encompassing morphological shifts between fission and fusion, can directly impact ROS levels in cancer cells. In this...
6.
Humphries B, Aliabouzar M, Quesada C, Bevoor A, Ho K, Farfel A, et al.
Adv Healthc Mater
. 2022 Feb;
11(10):e2101672.
PMID: 35106975
Cancer cells continually sense and respond to mechanical cues from the extracellular matrix (ECM). Interaction with the ECM can alter intracellular signaling cascades, leading to changes in processes that promote...