Alex F Chen
Overview
Explore the profile of Alex F Chen including associated specialties, affiliations and a list of published articles.
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Articles
179
Citations
3571
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Recent Articles
1.
Liu W, Li G, Shi J, Gao Y, Fang P, Zhao Y, et al.
Circ Res
. 2025 Mar;
PMID: 40035146
Background: Mounting evidence indicates that nuclear receptors play a critical regulatory role in platelet pathophysiology and thrombotic disorders. Although NR4A (the nuclear receptor subfamily 4 group A) plays an important...
2.
Tang Y, Wu J, Sun X, Tan S, Li W, Yin S, et al.
Cell Rep
. 2025 Feb;
44(3):115395.
PMID: 40009513
No abstract available.
3.
Wang Y, Li R, Tong R, Chen T, Sun M, Luo L, et al.
Nat Immunol
. 2025 Jan;
26(2):308-322.
PMID: 39881000
A comprehensive understanding of the evolution of the immune landscape in humans across the entire lifespan at single-cell transcriptional and protein levels, during development, maturation and senescence is currently lacking....
4.
Tian X, Peng Z, Wu Y, Cao Y, Li X, Li Y, et al.
J Am Heart Assoc
. 2025 Jan;
14(3):e034726.
PMID: 39846318
Background: Pulmonary arterial hypertension (PAH) is an incurable disease initiated by endothelial dysfunction, secondary to vascular inflammation and occlusive pulmonary arterial vascular remodeling, resulting in elevated pulmonary arterial pressure and...
5.
Liu H, Chen S, Xiang H, Xiao J, Zhao S, Zhang X, et al.
Prog Neuropsychopharmacol Biol Psychiatry
. 2025 Jan;
137:111256.
PMID: 39828081
The study investigates how Sphingosine-1-phosphate receptor 3 (S1PR3) and the Chronic Unpredictable Mild Stress (CUMS) affects depression-like behaviors. The S1P/S1PR3 signaling pathway is known to play a role in mood...
6.
Xing C, Shi L, Zhu L, Aguirre T, Qi J, Chen Y, et al.
Diabetes
. 2025 Jan;
PMID: 39792359
Diabetes is a major risk factor for cardiovascular disease, but the molecular mechanisms underlying diabetic vasculopathy have been elusive. Here we report that inositol hexakisphosphate kinase 1 (IP6K1) mediates hyperglycemia-induced...
7.
Feng W, Hong N, Wu Y, Huang J, Zhang Q, Liu G, et al.
J Mol Cell Cardiol
. 2025 Jan;
199:81-94.
PMID: 39746830
Abnormal valve development is the most common congenital heart malformation. The transcription factor Sox7 plays a critical role in the development of vascular and cardiac septation. However, it remains unclear...
8.
Li H, Zhang S, Huang X, Zhang Z, Liu K, Wang Q, et al.
Cell Discov
. 2024 Dec;
10(1):119.
PMID: 39622809
No abstract available.
9.
Shen Z, Wang J, Chen Y, Fang P, Yuan A, Chen A, et al.
Redox Biol
. 2024 Oct;
77:103397.
PMID: 39427444
Abdominal aortic aneurysm (AAA) is a life-threatening condition, but effective medications to prevent its progression and rupture are currently lacking. The nuclear receptor pregnane-X-receptor (PXR) plays a crucial role in...
10.
Peng Z, Luo X, Li X, Li Y, Wu Y, Tian Y, et al.
Hypertension
. 2024 Oct;
81(12):2430-2443.
PMID: 39403807
Background: Pulmonary hypertension (PH) is a fatal progressive disease characterized by pulmonary endothelial injury and occlusive pulmonary vascular remodeling. Lysosomal protease cathepsin L degrades essential molecules to participate in the...