Alessio Cantore
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Explore the profile of Alessio Cantore including associated specialties, affiliations and a list of published articles.
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26
Citations
1277
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Recent Articles
11.
Cesana D, Calabria A, Rudilosso L, Gallina P, Benedicenti F, Spinozzi G, et al.
Nat Med
. 2021 Jun;
27(8):1458-1470.
PMID: 34140705
Gene therapy (GT) has rapidly attracted renewed interest as a treatment for otherwise incurable diseases, with several GT products already on the market and many more entering clinical testing for...
12.
Vonada A, Tiyaboonchai A, Nygaard S, Posey J, Peters A, Winn S, et al.
Sci Transl Med
. 2021 Jun;
13(597).
PMID: 34108249
Gene therapy by integrating vectors is promising for monogenic liver diseases, especially in children where episomal vectors remain transient. However, reaching the therapeutic threshold with genome-integrating vectors is challenging. Therefore,...
13.
Soldi M, Sergi Sergi L, Unali G, Kerzel T, Cuccovillo I, Capasso P, et al.
Mol Ther Methods Clin Dev
. 2020 Dec;
19:411-425.
PMID: 33294490
Lentiviral vectors (LVs) are increasingly employed in gene and cell therapy. Standard laboratory production of LVs is not easily scalable, and research-grade LVs often contain contaminants that can interfere with...
14.
Cantore A, Naldini L
Haemophilia
. 2020 Jun;
27 Suppl 3:122-125.
PMID: 32537776
Over the last decade, the development of new treatments for haemophilia has progressed at a very rapid pace. Despite all the promising advances in protein products, the prospect offered by...
15.
Benechet A, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Bert N, et al.
Nature
. 2019 Oct;
574(7777):200-205.
PMID: 31582858
The responses of CD8 T cells to hepatotropic viruses such as hepatitis B range from dysfunction to differentiation into effector cells, but the mechanisms that underlie these distinct outcomes remain...
16.
Ciccocioppo R, Cantore A, Chaimov D, Orlando G
Intern Emerg Med
. 2019 Jun;
14(6):911-921.
PMID: 31203564
Regenerative medicine represents the forefront of health sciences and holds promises for the treatment and, possibly, the cure of a number of challenging conditions. It relies on the use of...
17.
Milani M, Annoni A, Moalli F, Liu T, Cesana D, Calabria A, et al.
Sci Transl Med
. 2019 May;
11(493).
PMID: 31118293
Liver-directed gene therapy for the coagulation disorder hemophilia showed safe and effective results in clinical trials using adeno-associated viral vectors to replace a functional coagulation factor, although some unmet needs...
18.
Annoni A, Gregori S, Naldini L, Cantore A
Cell Immunol
. 2018 May;
342:103802.
PMID: 29735164
Lentiviral vectors (LV) are widely used vehicles for gene transfer and therapy in pre-clinical animal models and clinical trials with promising safety and efficacy results. However, host immune responses against...
19.
Milani M, Annoni A, Bartolaccini S, Biffi M, Russo F, Di Tomaso T, et al.
EMBO Mol Med
. 2017 Aug;
9(11):1558-1573.
PMID: 28835507
Lentiviral vectors (LV) are powerful and versatile vehicles for gene therapy. However, their complex biological composition challenges large-scale manufacturing and raises concerns for applications, because particle components and contaminants may...
20.
Akbarpour M, Goudy K, Cantore A, Russo F, Sanvito F, Naldini L, et al.
Sci Transl Med
. 2015 May;
7(289):289ra81.
PMID: 26019217
Antigen (Ag)-specific tolerance in type 1 diabetes (T1D) in human has not been achieved yet. Targeting lentiviral vector (LV)-mediated gene expression to hepatocytes induces active tolerance toward the encoded Ag....