Alessandro Vasciaveo
Overview
Explore the profile of Alessandro Vasciaveo including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
225
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Recent Articles
1.
De Felice D, Alaimo A, Bressan D, Genovesi S, Marmocchi E, Annesi N, et al.
EMBO Rep
. 2024 Dec;
26(2):443-469.
PMID: 39633177
Retinoic acid (RA) signaling is a master regulator of vertebrate development with crucial roles in body axis orientation and tissue differentiation, including in the reproductive system. However, a mechanistic understanding...
2.
Valenti G, Laise P, Takahashi R, Wu F, Ruan T, Vasciaveo A, et al.
bioRxiv
. 2024 Sep;
PMID: 39257805
expression defines a rare population of cells in the normal pancreas whose frequency is increased at early stages of pancreatic tumorigenesis. The identity and the precise roles of expressing cells...
3.
Nunes de Almeida F, Vasciaveo A, Antao A, Zou M, Di Bernardo M, de Brot S, et al.
bioRxiv
. 2024 Sep;
PMID: 39253480
Summary: Using an unbiased forward mutagenesis screen in an autochthonous mouse model, we have investigated mechanistic determinants of aggressive prostate cancer. SIRT1 emerged as a key regulator of neuroendocrine prostate...
4.
Malagola E, Vasciaveo A, Ochiai Y, Kim W, Zheng B, Zanella L, et al.
Cell
. 2024 Jun;
187(12):3056-3071.e17.
PMID: 38848678
The currently accepted intestinal epithelial cell organization model proposes that Lgr5 crypt-base columnar (CBC) cells represent the sole intestinal stem cell (ISC) compartment. However, previous studies have indicated that Lgr5...
5.
De Felice D, Alaimo A, Bressan D, Genovesi S, Marmocchi E, Annesi N, et al.
bioRxiv
. 2024 Mar;
PMID: 38496627
Retinoic acid (RA) signaling is a master regulator of vertebrate development with crucial roles in directing body axis orientation and tissue differentiation, including in the reproductive system. However, a mechanistic...
6.
Leuzzi G, Vasciaveo A, Taglialatela A, Chen X, Firestone T, Hickman A, et al.
Cell
. 2024 Feb;
187(4):861-881.e32.
PMID: 38301646
Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor rejection. However, cancer cells often evade these responses by overexpressing immune checkpoint regulators, such as PD-L1. Here, we identify...
7.
Stokes M, Vasciaveo A, Small J, Zask A, Reznik E, Smith N, et al.
Cell Chem Biol
. 2023 Dec;
31(4):805-819.e9.
PMID: 38061356
Transcription factors have proven difficult to target with small molecules because they lack pockets necessary for potent binding. Disruption of protein expression can suppress targets and enable therapeutic intervention. To...
8.
Li J, Vasciaveo A, Karagiannis D, Sun Z, Chen X, Socciarelli F, et al.
bioRxiv
. 2023 Jul;
PMID: 37502956
The clinical use of potent androgen receptor (AR) inhibitors has promoted the emergence of novel subtypes of metastatic castration-resistant prostate cancer (mCRPC), including neuroendocrine prostate cancer (CRPC-NE), which is highly...
9.
Vasciaveo A, Arriaga J, Nunes de Almeida F, Zou M, Douglass E, Picech F, et al.
Cancer Discov
. 2022 Nov;
13(2):386-409.
PMID: 36374194
Significance: OncoLoop is a transcriptomic-based experimental and computational framework that can support rapid-turnaround coclinical studies to identify and validate drugs for individual patients, which can then be readily adapted to...
10.
Gil V, Miranda S, Riisnaes R, Gurel B, DAmbrosio M, Vasciaveo A, et al.
Cancer Res
. 2021 Nov;
81(24):6207-6218.
PMID: 34753775
It has been recognized for decades that ERBB signaling is important in prostate cancer, but targeting ERBB receptors as a therapeutic strategy for prostate cancer has been ineffective clinically. However,...