Alessandro Usiello
Overview
Explore the profile of Alessandro Usiello including associated specialties, affiliations and a list of published articles.
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122
Citations
2867
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Recent Articles
1.
Hassan A, di Vito R, Nuzzo T, Vidali M, Carlini M, Yadav S, et al.
Neurobiol Dis
. 2025 Feb;
207:106849.
PMID: 40010612
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by reduced expression of the survival motor neuron (SMN) protein. In addition to motor neuron survival, SMN deficiency affects the integrity...
2.
Rampino A, Garofalo M, Nuzzo T, Favia M, Saltarelli S, Masellis R, et al.
Schizophrenia (Heidelb)
. 2024 Dec;
10(1):115.
PMID: 39702391
Schizophrenia (SCZ) is a severe psychotic disorder characterized by a disruption in glutamatergic NMDA receptor (NMDAR)-mediated neurotransmission. Compelling evidence has revealed that NMDAR activation is not limited to L-glutamate, L-aspartate,...
3.
Hassan A, di Vito R, Nuzzo T, Vidali M, Carlini M, Yadav S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484528
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by reduced expression of the survival motor neuron (SMN) protein. In addition to motor neuron survival, SMN deficiency affects the integrity...
4.
Garofalo M, De Simone G, Motta Z, Nuzzo T, De Grandis E, Bruno C, et al.
Front Psychiatry
. 2024 Jul;
15:1408175.
PMID: 39050919
Introduction: Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental diseases characterized by different psychopathological manifestations and divergent clinical trajectories. Various alterations at glutamatergic synapses have been reported in both...
5.
Imarisio A, Yahyavi I, Gasparri C, Hassan A, Avenali M, Di Maio A, et al.
Transl Psychiatry
. 2024 Jul;
14(1):281.
PMID: 38982054
Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to stressors, and a huge socio-economic burden. Despite recent research...
6.
Maddaloni G, Barsotti N, Migliarini S, Giordano M, Nazzi S, Picchi M, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928178
Physiology and behavior are structured temporally to anticipate daily cycles of light and dark, ensuring fitness and survival. Neuromodulatory systems in the brain-including those involving serotonin and dopamine-exhibit daily oscillations...
7.
Imarisio A, Yahyavi I, Avenali M, Di Maio A, Buongarzone G, Galandra C, et al.
Neurobiol Dis
. 2024 Jan;
192:106413.
PMID: 38253208
We recently described increased D- and L-serine concentrations in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, the post-mortem caudate-putamen of human Parkinson's disease (PD) brains and the cerebrospinal fluid (CSF) of...
8.
Valsecchi V, Errico F, Bassareo V, Marino C, Nuzzo T, Brancaccio P, et al.
Commun Biol
. 2023 Nov;
6(1):1155.
PMID: 37957344
Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical...
9.
Serra M, Di Maio A, Bassareo V, Nuzzo T, Errico F, Servillo F, et al.
Neurobiol Dis
. 2023 Jul;
184:106226.
PMID: 37451474
Loss of dopaminergic midbrain neurons perturbs l-serine and d-serine homeostasis in the post-mortem caudate putamen (CPu) of Parkinson's disease (PD) patients. However, it is unclear whether the severity of dopaminergic...
10.
Di Maio A, Nuzzo T, Gilio L, Serra M, Buttari F, Errico F, et al.
Neurobiol Dis
. 2023 Jun;
184:106203.
PMID: 37336364
L-serine generated in astrocytes plays a pivotal role in modulating essential neurometabolic processes, while its enantiomer, D-serine, specifically regulates NMDA receptor (NMDAR) signalling. Despite their physiological relevance in modulating cerebral...