Alessandra Pontillo
Overview
Explore the profile of Alessandra Pontillo including associated specialties, affiliations and a list of published articles.
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Articles
86
Citations
1296
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Recent Articles
1.
Santiesteban-Lores L, Midon L, Franco T, de Oliveira L, Hibi S, Chiani Y, et al.
Immunogenetics
. 2024 Nov;
77(1):4.
PMID: 39614881
Leptospirosis is caused by pathogenic leptospires, posing a significant public health problem. Host susceptibility to Leptospira infection is a multifactorial trait, and the host's genetic background can influence both the...
2.
Leal V, Bork F, Mateo Tortola M, von Guilleaume J, Greve C, Bugl S, et al.
J Allergy Clin Immunol
. 2024 Nov;
155(2):569-582.
PMID: 39547282
Background: Inflammation is a double-edged state of immune activation that is required to resolve threats harmful to the host, but can also cause severe collateral damage. Polymorphonuclear neutrophils (PMNs), the...
3.
Leal V, Roa M, Cantoni J, Reis E, Lara A, Pontillo A
Immunol Invest
. 2024 Nov;
54(2):147-166.
PMID: 39495019
Background: Most of the investigations related to inflammasome activation during HIV infection have focused on the receptor NLRP3 and innate immune cells such as monocytes/macrophages. However, during the past years,...
4.
Ziliotto M, Ellwanger J, Kulmann-Leal B, Pontillo A, Chies J
Int J Immunogenet
. 2024 Oct;
51(6):369-379.
PMID: 39449652
Malaria is a mosquito-borne disease caused by Plasmodium parasites, responsible for a significant impact on public health in several tropical and sub-tropical countries. The majority of infection cases are classified...
5.
Mendonca L, Leal V, Roa M, Barros S, Kalil J, Pontillo A
Clin Exp Immunol
. 2024 Aug;
218(2):213-220.
PMID: 39119941
The aim of this study is to investigate the inflammasome dysregulation in peripheral blood leukocytes of VEXAS patients. The constitutive and in vitro triggered activation of inflammasome in PBMC and...
6.
Leal V, Pontillo A
Methods Mol Biol
. 2023 Aug;
2696:1-27.
PMID: 37578712
The innate immune response represents the first line of host defense, and it is able to detect pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) through a variety of...
7.
Fernandes F, Cambui R, Soares J, Reis E, Leal V, Pontillo A
Clin Transl Oncol
. 2023 Jun;
25(11):3277-3286.
PMID: 37328588
Purpose: Our group previously demonstrated that genetic variants in inflammasome genes contribute to protection against the establishment of human papilloma virus (HPV)-associated cervical carcinoma (CC). The objective of this study...
8.
Leal V, Andrade M, Teixeira F, Cambui R, Roa M, Marra L, et al.
Scand J Immunol
. 2022 Dec;
97(3):e13247.
PMID: 36541819
SARS-CoV-2 triggers inflammasome-dependent release of pro-inflammatory cytokine IL-1β and pyroptosis, therefore, contributes to the huge inflammatory response observed in severe COVID-19 patients. Less is known about the engagement of inflammasome...
9.
Leal V, Paulino L, Cambui R, Zupelli T, Yamada S, Oliveira L, et al.
Inflamm Res
. 2022 Nov;
72(10-11):1933-1940.
PMID: 36416944
Objective And Design: The heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome-related genes have been pointed as risk factors for...
10.
Dutra V, Leal V, Pontillo A
Inflamm Res
. 2022 Oct;
71(12):1403-1416.
PMID: 36266587
Background: The inflammasome is a cytosolic multi-protein complex responsible for the proteolytic maturation of pro-inflammatory cytokines IL-1ß and IL-18 and of gasdermin-D, which mediates membrane pore formation and the cytokines...