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Alejandro Valbuena

Explore the profile of Alejandro Valbuena including associated specialties, affiliations and a list of published articles. Areas
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Articles 30
Citations 275
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Recent Articles
1.
Mateu M, Valbuena A
Subcell Biochem . 2024 Dec; 105:823-878. PMID: 39738964
Virus particles (VPs) are naturally evolved nanomachines. Their outstanding molecular structures, physical and chemical properties, and biological activities make them potentially useful for many biomedical or technological applications. Natural VPs...
2.
Valiente L, Riomoros-Barahona V, Gil-Redondo J, Caston J, Valbuena A, Mateu M
J Mol Biol . 2024 Dec; 437(3):168922. PMID: 39725271
Human rhinoviruses (RV) are among the most frequent human pathogens. As major causative agents of common colds they originate serious socioeconomic problems and huge expenditure every year, and they also...
3.
Gil-Cantero D, Mata C, Valiente L, Rodriguez-Huete A, Valbuena A, Twarock R, et al.
Commun Biol . 2024 Nov; 7(1):1501. PMID: 39537894
The cryo-EM structure of the human rhinovirus B14 determined in this study reveals 13-bp RNA duplexes symmetrically bound to regions around each of the 30 two-fold axes in the icosahedral...
4.
Escrig J, Marcos-Alcalde I, Dominguez-Zotes S, Abia D, Gomez-Puertas P, Valbuena A, et al.
ACS Nano . 2024 Sep; 18(40):27465-27478. PMID: 39329375
The mechanisms that underlie the spontaneous and faithful assembly of virus particles are guiding the design of self-assembling protein-based nanostructures for biomedical or nanotechnological uses. In this study, the human...
5.
Valbuena A, Strobl K, Gil-Redondo J, Valiente L, de Pablo P, Mateu M
Small . 2023 Oct; 20(6):e2304722. PMID: 37806749
Infection of humans by many viruses is typically initiated by the internalization of a single virion in each of a few susceptible cells. Thus, the outcome of the infection process...
6.
Fuertes M, Mateos D, Valiente L, Rodriguez Huete A, Valbuena A, Mateu M
Viruses . 2023 May; 15(5). PMID: 37243141
The hollow protein capsids from a number of different viruses are being considered for multiple biomedical or nanotechnological applications. In order to improve the applied potential of a given viral...
7.
Luque D, Ortega-Esteban A, Valbuena A, Vilas J, Rodriguez-Huete A, Mateu M, et al.
J Mol Biol . 2023 Feb; 435(8):168024. PMID: 36828271
The biological function of macromolecular complexes depends not only on large-scale transitions between conformations, but also on small-scale conformational fluctuations at equilibrium. Information on the equilibrium dynamics of biomolecular complexes...
8.
Carrasco J, Anton R, Valbuena A, Pantoja-Uceda D, Mukhi M, Hervas R, et al.
Nat Commun . 2023 Jan; 14(1):466. PMID: 36709343
The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like domain in several neurodegenerative diseases. Aberrant TDP-43 aggregation arises upon phase de-mixing and transitions from liquid to solid...
9.
Valiente L, Lopez-Arguello S, Rodriguez-Huete A, Valbuena A, Mateu M
J Virol . 2022 Nov; 96(23):e0084022. PMID: 36374110
Human rhinovirus (HRV), one of the most frequent human pathogens, is the major causative agent of common colds. HRVs also cause or exacerbate severe respiratory diseases, such as asthma or...
10.
Dominguez-Zotes S, Valbuena A, Mateu M
Biophys J . 2022 Feb; 121(6):919-931. PMID: 35151634
This study investigates whether the biochemical and antiviral effects of organic compounds that bind different sites in the mature human immunodeficiency virus capsid may be related to the modulation of...