Alejandra R Alvarez
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Explore the profile of Alejandra R Alvarez including associated specialties, affiliations and a list of published articles.
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41
Citations
965
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Recent Articles
11.
Contreras P, Tapia P, Gonzalez-Hodar L, Peluso I, Soldati C, Napolitano G, et al.
iScience
. 2020 Nov;
23(11):101691.
PMID: 33163944
The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase...
12.
Picon-Pages P, Gutierrez D, Barranco-Almohalla A, Crepin G, Tajes M, Ill-Raga G, et al.
Oxid Med Cell Longev
. 2020 Oct;
2020:2739459.
PMID: 33014268
Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (A) aggregates generate free radicals. Moreover, the aggregation of A is increased by oxidative stress, and the neurotoxicity...
13.
Tomita H, Cornejo F, Aranda-Pino B, Woodard C, Rioseco C, Neel B, et al.
Cell Rep
. 2020 Jan;
30(1):215-228.e5.
PMID: 31914388
PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant neural development by perturbing neurogenesis in the murine...
14.
Gutierrez D, Vargas L, Chandia-Cristi A, de la Fuente C, Leal N, Alvarez A
Front Cell Neurosci
. 2019 Dec;
13:526.
PMID: 31849613
Spine pathology has been implicated in the early onset of Alzheimer's disease (AD), where Aβ-Oligomers (AβOs) cause synaptic dysfunction and loss. Previously, we described that pharmacological inhibition of c-Abl prevents...
15.
Oyarzun J, Lagos J, Vazquez M, Valls C, de la Fuente C, Yuseff M, et al.
Biochim Biophys Acta Mol Basis Dis
. 2019 Mar;
1865(6):1076-1087.
PMID: 30904612
Lysosomes are dynamic organelles, which can fuse with a variety of targets and undergo constant regeneration. They can move along microtubules in a retrograde and anterograde fashion by using motor...
16.
Morales-Zavala F, Casanova-Morales N, Gonzalez R, Chandia-Cristi A, Estrada L, Alvizu I, et al.
J Nanobiotechnology
. 2018 Aug;
16(1):60.
PMID: 30097010
Background: Stable and non-toxic fluorescent markers are gaining attention in molecular diagnostics as powerful tools for enabling long and reliable biological studies. Such markers should not only have a long...
17.
Morales-Zavala F, Arriagada H, Hassan N, Velasco C, Riveros A, Alvarez A, et al.
Nanomedicine
. 2017 Jul;
13(7):2341-2350.
PMID: 28673851
The properties of nanometric materials make nanotechnology a promising platform for tackling problems of contemporary medicine. In this work, gold nanorods were synthetized and stabilized with polyethylene glycols and modified...
18.
Balboa E, Castro J, Pinochet M, Cancino G, Matias N, Saez P, et al.
Redox Biol
. 2017 Mar;
12:274-284.
PMID: 28282615
MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated in cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria, in toxin-induced resistance, and in mitochondrial...
19.
Estrada L, Chamorro D, Yanez M, Gonzalez M, Leal N, von Bernhardi R, et al.
J Alzheimers Dis
. 2016 Aug;
54(3):1193-1205.
PMID: 27567806
One of the pathological hallmarks of Alzheimer's disease (AD) is the presence of amyloid plaques, which are deposits of misfolded and aggregated amyloid-beta peptide (Aβ). The role of the c-Abl...
20.
Contreras P, Gonzalez-Zuniga M, Gonzalez-Hodar L, Yanez M, Dulcey A, Marugan J, et al.
Biochim Biophys Acta
. 2015 Nov;
1859(2):269-79.
PMID: 26603102
Background: Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of free cholesterol in lysosomes. There are currently no effective FDA-approved treatments for NPC, although...