Alec Falkenham
Overview
Explore the profile of Alec Falkenham including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
156
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Recent Articles
1.
Foley M, Searle S, Toloue A, Booth R, Falkenham A, Falzarano D, et al.
EClinicalMedicine
. 2021 Jul;
37:100975.
PMID: 34222846
Background: The SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has led to more than 165 million COVID-19 cases and >3.4 million deaths worldwide. Epidemiological analysis has revealed that the risk...
2.
Wong C, Falkenham A, Myers T, Legare J
J Renin Angiotensin Aldosterone Syst
. 2018 Mar;
19(1):1470320318759358.
PMID: 29575960
Introduction: Transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) are often described as the initial pro-fibrotic mediators upregulated early in fibrosis models dependent on angiotensin II (Ang-II). In...
3.
Falkenham A, Saraswat M, Wong C, Gawdat K, Myers T, Begum J, et al.
ESC Heart Fail
. 2017 Jul;
5(1):107-114.
PMID: 28737273
Aims: Previous studies have examined risk factors for the development of heart failure (HF) subsequent to acute coronary syndrome (ACS). Our study seeks to clarify the clinical variables that best...
4.
Falkenham A, Myers T, Wong C, Legare J
Cardiovasc Pathol
. 2016 Jun;
25(5):390-8.
PMID: 27327107
Background: Macrophages (MΦ) are functionally diverse and dynamic. Until recently, cardiac MΦ were assumed to be monocyte derived; however, resident cardiac MΦ (rCMΦ), present at baseline, were identified in myocardia...
5.
Falkenham A, De Antueno R, Rosin N, Betsch D, Lee T, Duncan R, et al.
Am J Pathol
. 2015 Mar;
185(4):927-42.
PMID: 25794704
Macrophages are increasingly recognized as a potential therapeutic target in myocardial fibrosis via interactions with fibroblasts. We have characterized macrophage depletion and inhibition of nonclassical macrophage migration, in addition to...
6.
Rosin N, Sopel M, Falkenham A, Lee T, Legare J
Am J Pathol
. 2015 Feb;
185(3):631-42.
PMID: 25701883
Heart failure, the leading cause of hospitalization of elderly patients, is correlated with myocardial fibrosis (ie, deposition of excess extracellular matrix proteins such as collagen). A key regulator of collagen...
7.
Rosin N, Gareau A, Betsch D, Falkenham A, Sopel M, Lee T, et al.
Fibrogenesis Tissue Repair
. 2014 Apr;
7:6.
PMID: 24721281
Background: Myocardial fibrosis is a pathological process that is characterized by disrupted regulation of extracellular matrix proteins resulting in permanent scarring of the heart tissue and eventual diastolic heart failure....
8.
Falkenham A, Sopel M, Rosin N, Lee T, Issekutz T, Legare J
Am J Pathol
. 2013 Jun;
183(2):459-69.
PMID: 23731726
Fibroblast progenitor cells (fibrocytes) are important to the development of myocardial fibrosis and are suggested to migrate to the heart via CXCL12 and chemokine ligand (CCL) 2. We hypothesized that...
9.
Rosin N, Falkenham A, Sopel M, Lee T, Legare J
Am J Pathol
. 2013 Jan;
182(3):714-26.
PMID: 23287510
Exposure of rodents to angiotensin II (AngII) is a common model of fibrosis. We have previously shown that cellular infiltration of bone marrow-derived progenitor cells (fibrocytes) occurs before deposition of...
10.
Rosin N, Sopel M, Falkenham A, Myers T, Legare J
Hypertens Res
. 2012 Jan;
35(4):449-56.
PMID: 22258030
Activation of the renin-angiotensin system (RAS) is thought to promote myocardial fibrosis. However, it is unclear whether this physiological fibrotic response results from chronic hemodynamic stress or from direct cellular...