Albrecht Messerschmidt
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Explore the profile of Albrecht Messerschmidt including associated specialties, affiliations and a list of published articles.
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28
Citations
530
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Recent Articles
11.
Berry I, Dym O, Esnouf R, Harlos K, Meged R, Perrakis A, et al.
Acta Crystallogr D Biol Crystallogr
. 2006 Sep;
62(Pt 10):1137-49.
PMID: 17001091
This paper reviews the developments in high-throughput and nanolitre-scale protein crystallography technologies within the remit of workpackage 4 of the Structural Proteomics In Europe (SPINE) project since the project's inception...
12.
Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site
Debela M, Magdolen V, Grimminger V, Sommerhoff C, Messerschmidt A, Huber R, et al.
J Mol Biol
. 2006 Sep;
362(5):1094-107.
PMID: 16950394
Human tissue kallikrein 4 (hK4) belongs to a 15-member family of closely related serine proteinases. hK4 is predominantly expressed in prostate, activates hK3/PSA, and is up-regulated in prostate and ovarian...
13.
Li C, Yanagisawa S, Martins B, Messerschmidt A, Banfield M, Dennison C
Proc Natl Acad Sci U S A
. 2006 May;
103(19):7258-63.
PMID: 16651527
The main active-site loop of the copper-binding protein azurin (a cupredoxin) has been shortened from C(112)TFPGH(117)SALM(121) to C(112)TPH(115)PFM(118) (the native loop from the cupredoxin amicyanin) and also to C(112)TPH(115)PM(117). The...
14.
Einsle O, Niessen H, Abt D, Seiffert G, Schink B, Huber R, et al.
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2006 Mar;
61(Pt 3):299-301.
PMID: 16511024
Acetylene hydratase is a tungsten-containing hydroxylase that converts acetylene to acetaldehyde in a unique reaction that requires a strong reductant. The subsequent disproportionation of acetaldehyde yields acetate and ethanol. Crystals...
15.
Boll M, Schink B, Messerschmidt A, Kroneck P
Biol Chem
. 2005 Oct;
386(10):999-1006.
PMID: 16218872
The molybdenum enzymes 4-hydroxybenzoyl-CoA reductase and pyrogallol-phloroglucinol transhydroxylase and the tungsten enzyme acetylene hydratase catalyze reductive dehydroxylation reactions, i.e., transhydroxylation between phenolic residues and the addition of water to a...
16.
Buckel W, Martins B, Messerschmidt A, Golding B
Biol Chem
. 2005 Oct;
386(10):951-9.
PMID: 16218867
Most dehydratases catalyse the elimination of water from beta-hydroxy ketones, beta-hydroxy carboxylic acids or beta-hydroxyacyl-CoA. The electron-withdrawing carbonyl functionalities acidify the alpha-hydrogens to enable their removal by basic amino acid...
17.
Messerschmidt A, Macieira S, Velarde M, Badeker M, Benda C, Jestel A, et al.
J Mol Biol
. 2005 Aug;
352(4):918-31.
PMID: 16125198
Atypical protein kinases C (aPKCs) play critical roles in signaling pathways that control cell growth, differentiation and survival. Therefore, they constitute attractive targets for the development of novel therapeutics against...
18.
Martins B, Macedo-Ribeiro S, Bresser J, Buckel W, Messerschmidt A
FEBS J
. 2005 Jan;
272(1):269-81.
PMID: 15634349
NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase (HGDH) catalyses the reduction of 2-oxoglutarate to (R)-2-hydroxyglutarate and belongs to the d-2-hydroxyacid NAD(+)-dependent dehydrogenase (d-2-hydroxyacid dehydrogenase) protein family. Its crystal structure was determined by phase combination...
19.
Koch M, Velarde M, Harrison M, Echt S, Fischer M, Messerschmidt A, et al.
J Am Chem Soc
. 2005 Jan;
127(1):158-66.
PMID: 15631465
Umecyanin (UMC) is a type 1 copper-containing protein which originates from horseradish roots and belongs to the stellacyanin subclass of the phytocyanins, a ubiquitous family of plant cupredoxins. The crystal...
20.
Martins B, Dobbek H, Cinkaya I, Buckel W, Messerschmidt A
Proc Natl Acad Sci U S A
. 2004 Oct;
101(44):15645-9.
PMID: 15496473
Dehydratases catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the elimination of water. The 1.6-A resolution crystal structure of 4-hydroxybutyryl-CoA dehydratase from the gamma-aminobutyrate-fermenting Clostridium aminobutyricum...