Alberta Iacono
Overview
Explore the profile of Alberta Iacono including associated specialties, affiliations and a list of published articles.
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11
Citations
477
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Recent Articles
1.
Panfili E, Mondanelli G, Orabona C, Belladonna M, Gargaro M, Fallarino F, et al.
Hum Mol Genet
. 2021 Mar;
30(3-4):265-276.
PMID: 33693650
Mutations in the WFS1 gene, encoding wolframin (WFS1), cause endoplasmic reticulum (ER) stress and are associated with a rare autosomal-recessive disorder known as Wolfram syndrome (WS). WS is clinically characterized...
2.
Iacono A, Pompa A, De Marchis F, Panfili E, Greco F, Coletti A, et al.
EMBO Rep
. 2020 Nov;
21(12):e49756.
PMID: 33159421
Knowledge of a protein's spatial dynamics at the subcellular level is key to understanding its function(s), interactions, and associated intracellular events. Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic enzyme that...
3.
Mondanelli G, Coletti A, Greco F, Pallotta M, Orabona C, Iacono A, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(7):3848-3857.
PMID: 32024760
l-tryptophan (Trp), an essential amino acid for mammals, is the precursor of a wide array of immunomodulatory metabolites produced by the kynurenine and serotonin pathways. The kynurenine pathway is a...
4.
Gargaro M, Vacca C, Massari S, Scalisi G, Manni G, Mondanelli G, et al.
Front Immunol
. 2019 Sep;
10:1973.
PMID: 31481962
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first step in the kynurenine pathway of tryptophan (Trp) degradation that produces several biologically active Trp metabolites. L-kynurenine (Kyn), the first byproduct by IDO1,...
5.
Mondanelli G, Iacono A, Allegrucci M, Puccetti P, Grohmann U
Front Immunol
. 2019 Jul;
10:1565.
PMID: 31354721
No abstract available.
6.
Mondanelli G, Iacono A, Carvalho A, Orabona C, Volpi C, Pallotta M, et al.
Autoimmun Rev
. 2019 Feb;
18(4):334-348.
PMID: 30797943
In mammals, amino acid metabolism has evolved to control immune responses. Autoimmune diseases are heterogeneous conditions that involve the breakdown of tolerogenic circuitries and consequent activation of autoreactive immune cells....
7.
Orabona C, Mondanelli G, Pallotta M, Carvalho A, Albini E, Fallarino F, et al.
JCI Insight
. 2018 Mar;
3(6).
PMID: 29563329
A defect in indoleamine 2,3-dioxygenase 1 (IDO1), which is responsible for immunoregulatory tryptophan catabolism, impairs development of immune tolerance to autoantigens in NOD mice, a model for human autoimmune type...
8.
Grohmann U, Mondanelli G, Belladonna M, Orabona C, Pallotta M, Iacono A, et al.
Cytokine Growth Factor Rev
. 2017 May;
35:37-45.
PMID: 28545736
Indoleamine 2,3-dioxygenases (IDOs) - belonging in the heme dioxygenase family and degrading tryptophan - are responsible for the de novo synthesis of nicotinamide adenine dinucleotide (NAD). As such, they are...
9.
Mondanelli G, Bianchi R, Pallotta M, Orabona C, Albini E, Iacono A, et al.
Immunity
. 2017 Feb;
46(2):233-244.
PMID: 28214225
Arginase 1 (Arg1) and indoleamine 2,3-dioxygenase 1 (IDO1) are immunoregulatory enzymes catalyzing the degradation of l-arginine and l-tryptophan, respectively, resulting in local amino acid deprivation. In addition, unlike Arg1, IDO1...
10.
Chalise J, Pallotta M, Narendra S, Carlsson B, Iacono A, Namale J, et al.
J Immunol
. 2016 Sep;
197(8):3142-3151.
PMID: 27647832
IFN-α prevents Ag-induced arthritis (AIA), and in this study we investigated the role of IDO1 and TGF-β signaling for this anti-inflammatory property of IFN-α. Arthritis was induced by methylated BSA...