Albert Isidro-Llobet
Overview
Explore the profile of Albert Isidro-Llobet including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
29
Citations
982
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Lenhard S, McAlexander A, Virtue A, Fieles W, Skedzielewski T, Rambo M, et al.
J Pharmacol Exp Ther
. 2019 Apr;
370(3):786-795.
PMID: 30936291
Autosomal dominant polycystic kidney disease (ADPKD) is a leading monogenetic cause of end-stage renal disease with limited therapeutic repertoire. A targeted drug delivery strategy that directs a small molecule to...
12.
Isidro-Llobet A, Kenworthy M, Mukherjee S, Kopach M, Wegner K, Gallou F, et al.
J Org Chem
. 2019 Mar;
84(8):4615-4628.
PMID: 30900880
In recent years, there has been a growing interest in therapeutic peptides within the pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 in clinical trials,...
13.
Arbour C, Belavek K, Tariq R, Mukherjee S, Tom J, Isidro-Llobet A, et al.
J Org Chem
. 2018 Dec;
84(2):1035-1041.
PMID: 30566351
We establish herein conditions for the cyclization of unprotected N-acyl urea-linked peptides to form macrocyclic peptides mediated by N-terminal cysteine. We report a detailed investigation of the parameters of the...
14.
Infante Lara L, Fenner S, Ratcliffe S, Isidro-Llobet A, Hann M, Bax B, et al.
Nucleic Acids Res
. 2018 Feb;
46(5):2218-2233.
PMID: 29447373
Etoposide and other topoisomerase II-targeted drugs are important anticancer therapeutics. Unfortunately, the safe usage of these agents is limited by their indiscriminate induction of topoisomerase II-mediated DNA cleavage throughout the...
15.
Vantourout J, Miras H, Isidro-Llobet A, Sproules S, Watson A
J Am Chem Soc
. 2017 Mar;
139(13):4769-4779.
PMID: 28266843
We report an investigation of the Chan-Lam amination reaction. A combination of spectroscopy, computational modeling, and crystallography has identified the structures of key intermediates and allowed a complete mechanistic description...
16.
Vantourout J, Law R, Isidro-Llobet A, Atkinson S, Watson A
J Org Chem
. 2016 Apr;
81(9):3942-50.
PMID: 27045570
The Chan-Evans-Lam reaction is a valuable C-N bond forming process. However, aryl boronic acid pinacol (BPin) ester reagents can be difficult coupling partners that often deliver low yields, in particular...
17.
Muir C, Vantourout J, Isidro-Llobet A, Macdonald S, Watson A
Org Lett
. 2015 Dec;
17(24):6030-3.
PMID: 26632981
Formal homologation of sp(2)-hybridized boronic acids is achieved via cross-coupling of boronic acids with conjunctive haloaryl BMIDA components in the presence of a suitably balanced basic phase. The utility of...
18.
Isidro-Llobet A, Hadje Georgiou K, Galloway W, Giacomini E, Hansen M, Mendez-Abt G, et al.
Org Biomol Chem
. 2015 Mar;
13(15):4570-80.
PMID: 25778821
Macrocyclic peptidomimetics are associated with a broad range of biological activities. However, despite such potentially valuable properties, the macrocyclic peptidomimetic structural class is generally considered as being poorly explored within...
19.
Isidro-Llobet A, Murillo T, Bello P, Cilibrizzi A, Hodgkinson J, Galloway W, et al.
Proc Natl Acad Sci U S A
. 2011 Mar;
108(17):6793-8.
PMID: 21383137
Structurally diverse libraries of novel small molecules represent important sources of biologically active agents. In this paper we report the development of a diversity-oriented synthesis strategy for the generation of...
20.
Kenwright J, Galloway W, Blackwell D, Isidro-Llobet A, Hodgkinson J, Wortmann L, et al.
Chemistry
. 2011 Feb;
17(10):2981-6.
PMID: 21290435
Herein, a new copper-catalysed strategy for the synthesis of rare nitrogen-linked seven-, eight- and nine-membered biaryl ring systems is described. It is proposed that the reaction proceeds through a highly...