Alba Carreras
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Explore the profile of Alba Carreras including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
1549
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Recent Articles
1.
Engstrom Ruud L, Font-Girones F, Zajdel J, Kern L, Teixidor-Deulofeu J, Manneras-Holm L, et al.
Cell Rep
. 2024 Mar;
43(4):113960.
PMID: 38507407
GFRAL-expressing neurons actuate aversion and nausea, are targets for obesity treatment, and may mediate metformin effects by long-term GDF15-GFRAL agonism. Whether GFRAL neurons acutely regulate glucose and energy homeostasis is,...
2.
Molinaro A, Koh A, Wu H, Schoeler M, Faggi M, Carreras A, et al.
Mol Metab
. 2020 Apr;
37:100997.
PMID: 32305515
Objective: Gut-derived inflammatory factors can impair glucose homeostasis, but the underlying mechanisms are not fully understood. In this study, we investigated how hepatic gene expression is regulated by gut colonization...
3.
Lee S, Priest C, Bjursell M, Gao J, Arneson D, Ahn I, et al.
Nat Metab
. 2020 Feb;
1(11):1089-1100.
PMID: 32072135
Liver X receptors limit cellular lipid uptake by stimulating the transcription of Inducible Degrader of the LDL Receptor (IDOL), an E3 ubiquitin ligase that targets lipoprotein receptors for degradation. The...
4.
Carreras A, Pane L, Nitsch R, Madeyski-Bengtson K, Porritt M, Akcakaya P, et al.
BMC Biol
. 2019 Jan;
17(1):4.
PMID: 30646909
Background: Plasma concentration of low-density lipoprotein (LDL) cholesterol is a well-established risk factor for cardiovascular disease. Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9), which regulates cholesterol homeostasis, has recently...
5.
Carreras A, Backhed F
Immunity
. 2018 Nov;
49(5):788-790.
PMID: 30462992
While the commensal microbiota is considered an important regulator of immunity and metabolism, the mechanisms controlling the interplay between diet, cytokine signaling, and the microbiota in atherosclerosis remains unknown. In...
6.
Koh A, Molinaro A, Stahlman M, Khan M, Schmidt C, Manneras-Holm L, et al.
Cell
. 2018 Nov;
175(4):947-961.e17.
PMID: 30401435
Interactions between the gut microbiota, diet, and the host potentially contribute to the development of metabolic diseases. Here, we identify imidazole propionate as a microbially produced histidine-derived metabolite that is...
7.
Akcakaya P, Bobbin M, Guo J, Malagon-Lopez J, Clement K, Garcia S, et al.
Nature
. 2018 Sep;
561(7723):416-419.
PMID: 30209390
CRISPR-Cas genome-editing nucleases hold substantial promise for developing human therapeutic applications but identifying unwanted off-target mutations is important for clinical translation. A well-validated method that can reliably identify off-targets in...
8.
Warner A, Kjellstedt A, Carreras A, Bottcher G, Peng X, Seale P, et al.
Am J Physiol Endocrinol Metab
. 2016 Oct;
311(6):E901-E910.
PMID: 27780820
Activation of brown adipose tissue (BAT) and browning of white adipose tissue (WAT) present potential new therapies for obesity and type 2 diabetes. Here, we examined the effects of β-adrenergic...
9.
Poroyko V, Carreras A, Khalyfa A, Khalyfa A, Leone V, Peris E, et al.
Sci Rep
. 2016 Oct;
6:35405.
PMID: 27739530
Chronic sleep fragmentation (SF) commonly occurs in human populations, and although it does not involve circadian shifts or sleep deprivation, it markedly alters feeding behaviors ultimately promoting obesity and insulin...
10.
Zheng J, Almendros I, Wang Y, Zhang S, Carreras A, Qiao Z, et al.
Oncoimmunology
. 2015 May;
4(2):e976057.
PMID: 25949873
The molecular mechanisms underlying how sleep fragmentation (SF) influences cancer growth and progression remain largely elusive. Here, we present evidence that SF reduced ROS production by downregulating expression and activity...