Alasdair R C Smith
Overview
Explore the profile of Alasdair R C Smith including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
57
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Recent Articles
1.
Park Y, Pacitto A, Bayliss T, Cleghorn L, Wang Z, Hartman T, et al.
ACS Infect Dis
. 2016 Oct;
3(1):18-33.
PMID: 27704782
A potent, noncytotoxic indazole sulfonamide was identified by high-throughput screening of >100,000 synthetic compounds for activity against Mycobacterium tuberculosis (Mtb). This noncytotoxic compound did not directly inhibit cell wall biogenesis...
2.
Palin R, Clark J, Evans L, Feilden H, Fletcher D, Hamilton N, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(22):6441-6.
PMID: 19818611
A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore...
3.
Palin R, Barn D, Clark J, Cottney J, Cowley P, Crockatt M, et al.
Bioorg Med Chem Lett
. 2005 Jan;
15(3):589-93.
PMID: 15664818
A series of 3-phenoxypropyl piperidine analogues have been discovered as novel ORL1 receptor agonists. Structure-activity relationships have been explored around the 3-phenoxypropyl region with several potent and selective analogues identified.