Alan Mackay-Sim
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Explore the profile of Alan Mackay-Sim including associated specialties, affiliations and a list of published articles.
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112
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4252
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Recent Articles
1.
Farnum Z, Mani R, Bindoff A, Wilson R, Fiotakis A, Stephens J, et al.
J Neurochem
. 2024 Nov;
169(2):e16263.
PMID: 39556451
Stressful life events and glucocorticoid (stress) hormones appear to increase the risk of Alzheimer's disease and hasten its progression, but the reasons for this remain unclear. One potential explanation is...
2.
Leeson H, Aguado J, Gomez-Inclan C, Chaggar H, Fard A, Hunter Z, et al.
Neurobiol Dis
. 2024 Jun;
199:106562.
PMID: 38876322
Ataxia Telangiectasia (AT) is a rare disorder caused by mutations in the ATM gene and results in progressive neurodegeneration for reasons that remain poorly understood. In addition to its central...
3.
Wali G, Siow S, Liyanage E, Kumar K, Mackay-Sim A, Sue C
Front Neurosci
. 2023 May;
17:1073516.
PMID: 37144097
HSP is the most common form of hereditary spastic paraplegia (HSP), a neurodegenerative disease causing lower limb spasticity. Previous studies using HSP patient-derived induced pluripotent stem cell cortical neurons have...
4.
Rantanen L, Bitar M, Lampinen R, Stewart R, Quek H, Oikari L, et al.
Cells
. 2022 Oct;
11(20).
PMID: 36291125
An early symptom of Alzheimer's disease (AD) is an impaired sense of smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people...
5.
Lampinen R, Fazaludeen M, Avesani S, Ord T, Penttila E, Lehtola J, et al.
Cells
. 2022 Feb;
11(4).
PMID: 35203328
Olfaction is orchestrated by olfactory mucosal cells located in the upper nasal cavity. Olfactory dysfunction manifests early in several neurodegenerative disorders including Alzheimer's disease, however, disease-related alterations to the olfactory...
6.
Leeson H, Hunter Z, Chaggar H, Mackay-Sim A, Wolvetang E
Stem Cell Res
. 2021 Sep;
56:102527.
PMID: 34507143
Human olfactory neurosphere-derived (ONS) cells are derived from the olfactory mucosa and display some progenitor- and neuronal cell-like properties, making them useful models of neurological disorders. However, they lack several...
7.
Leeson H, Hunter Z, Chaggar H, Lavin M, Mackay-Sim A, Wolvetang E
Stem Cell Res
. 2021 Sep;
56:102528.
PMID: 34507142
Ataxia Telangiectasia is a rare autosomal recessive disorder caused by a mutated ATM gene. The most debilitating symptom of Ataxia Telangiectasia is the progressive neurodegeneration of the cerebellum, though the...
8.
Tee J, Mackay-Sim A
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502103
Cell migration is critical for brain development and linked to several neurodevelopmental disorders, including schizophrenia. We have shown previously that cell migration is dysregulated in olfactory neural stem cells from...
9.
Aguado J, Chaggar H, Gomez-Inclan C, Shaker M, Leeson H, Mackay-Sim A, et al.
Aging Cell
. 2021 Aug;
20(9):e13468.
PMID: 34459078
Ataxia-telangiectasia (A-T) is a genetic disorder caused by the lack of functional ATM kinase. A-T is characterized by chronic inflammation, neurodegeneration and premature ageing features that are associated with increased...
10.
Wali G, Berkovsky S, Whiten D, Mackay-Sim A, Sue C
Sci Rep
. 2021 Aug;
11(1):16635.
PMID: 34404843
A central need for neurodegenerative diseases is to find curative drugs for the many clinical subtypes, the causative gene for most cases being unknown. This requires the classification of disease...