Alan L Sewell
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Explore the profile of Alan L Sewell including associated specialties, affiliations and a list of published articles.
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5
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27
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Recent Articles
1.
Felion C, Lopez-Gonzalez R, Sewell A, Marquez R, Gauchotte-Lindsay C
ACS Omega
. 2022 Nov;
7(45):41284-41295.
PMID: 36406552
Biodegradation of estrogen hormone micropollutants is a well-established approach toward their remediation. Fluorescently labeled substrates are used extensively for rapid, near-real-time analysis of biological processes and are a potential tool...
2.
Tjhin E, Spry C, Sewell A, Hoegl A, Barnard L, Sexton A, et al.
PLoS Pathog
. 2018 Apr;
14(4):e1006918.
PMID: 29614109
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK)....
3.
Spry C, Sewell A, Hering Y, Villa M, Weber J, Hobson S, et al.
Eur J Med Chem
. 2017 Dec;
143:1139-1147.
PMID: 29233590
Survival of the human malaria parasite Plasmodium falciparum is dependent on pantothenate (vitamin B), a precursor of the fundamental enzyme cofactor coenzyme A. CJ-15,801, an enamide analogue of pantothenate isolated...
4.
Percy J, McCarter A, Sewell A, Sloan N, Kennedy A, Hirst D
Chemistry
. 2015 Nov;
21(52):19119-27.
PMID: 26564395
Palladium(II)-catalysed cycloalkenylation (Saegusa-Ito cyclisation) has been used for the first time to transform difluorinated silylenol ethers to difluorinated cycloalkenones under mild conditions. The silylenol ether precursors were prepared in two...
5.
Sewell A, Villa M, Matheson M, Whittingham W, Marquez R
Org Lett
. 2011 Jan;
13(4):800-3.
PMID: 21250753
The fast and efficient syntheses of pantothenic acid and the antiparasitic agent CJ-15,801 have been achieved starting from a common imide unit through the selective manipulation of enamide intermediates.