Alan Herbert
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Explore the profile of Alan Herbert including associated specialties, affiliations and a list of published articles.
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51
Citations
1441
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Recent Articles
1.
Herbert A
Biol Lett
. 2025 Jan;
21(1):20240635.
PMID: 39837490
This paper is focused on the origins of the contemporary genetic code. A novel explanation is proposed for how the mapping of nucleotides in DNA to amino acids in proteins...
2.
Herbert A
Int J Mol Sci
. 2024 Oct;
25(19).
PMID: 39408629
As with all new fields of discovery, work on the biological role of G-quadruplexes (GQs) has produced a number of results that at first glance are quite baffling, sometimes because...
3.
Herbert A
Front Neurosci
. 2024 Oct;
18:1445540.
PMID: 39371608
Tetrapod endogenous retroelements (ERE) encode proteins that have been exapted to perform many roles in development and also in innate immunity, including GAG (group specific antigen) proteins from the ERE...
4.
Herbert A
R Soc Open Sci
. 2024 Aug;
11(6):240080.
PMID: 39092141
The Zα fold specifically binds to both Z-DNA and Z-RNA, left-handed nucleic acid structures that form under physiological conditions and are encoded by flipons. I trace the Zα fold back...
5.
Beknazarov N, Konovalov D, Herbert A, Poptsova M
Sci Rep
. 2024 Aug;
14(1):17786.
PMID: 39090226
A long-standing question concerns the role of Z-DNA in transcription. Here we use a deep learning approach DeepZ that predicts Z-flipons based on DNA sequence, structural properties of nucleotides and...
6.
Herbert A
Genes Immun
. 2024 May;
25(4):265-276.
PMID: 38811682
Osteogenesis imperfecta type 10 (OI10) is caused by loss of function codon variants in the gene SERPINH1 that encodes heat shock protein 47 (HSP47), rather than in a gene specifying...
7.
Pisetsky D, Herbert A
Ann Rheum Dis
. 2024 May;
83(7):830-837.
PMID: 38749573
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by antibodies to DNA (anti-DNA) and other nuclear macromolecules. Anti-DNA antibodies are markers for classification and disease activity and promote...
8.
Herbert A
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003672
Cell responses are usually viewed as transitive events with fixed inputs and outputs that are regulated by feedback loops. In contrast, directed cycles (DCs) have all nodes connected, and the...
9.
Herbert A
J Biol Chem
. 2023 Aug;
299(9):105140.
PMID: 37544644
The role of alternate DNA conformations such as Z-DNA in the regulation of transcription is currently underappreciated. These structures are encoded by sequences called flipons, many of which are enriched...
10.
Guo X, Liu S, Sheng Y, Zenati M, Billiar T, Herbert A, et al.
Cell Rep
. 2023 Jul;
42(7):112733.
PMID: 37421629
Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in which severe inflammation occurs in the brain due to innate immune activation. Here, we analyze the RNA-editing status and...