Alan C Foster
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Explore the profile of Alan C Foster including associated specialties, affiliations and a list of published articles.
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62
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1013
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Recent Articles
1.
Jung B, Kuthubutheen J, Sharon J, Foster A, Erickson S, Peris H, et al.
Otol Neurotol
. 2024 Nov;
46(1):80-87.
PMID: 39589784
Objective: To use animal pharmacokinetic data and FluidSIM modeling to estimate human dexamethasone perilymph concentrations from plasma concentration measurements over time following a single intratympanic administration of SPT-2101. Study Design:...
2.
Vink H, Ramekers D, Foster A, Versnel H
Hear Res
. 2023 Oct;
439:108895.
PMID: 37837701
The auditory nerve typically degenerates following loss of cochlear hair cells or synapses. In the case of hair cell loss neural degeneration hinders restoration of hearing through a cochlear implant,...
3.
Foster A, Szobota S, Piu F, Jacques B, Moore D, Sanchez V, et al.
J Acoust Soc Am
. 2022 Jul;
151(6):3937.
PMID: 35778165
Currently, there are no approved medicines available for the treatment of hearing loss. However, research over the past two decades has contributed to a growing understanding of the pathological mechanisms...
4.
Foster A, Jacques B, Piu F
Pharmacol Res Perspect
. 2022 May;
10(3):e00970.
PMID: 35599339
Despite a prevalence greater than cancer or diabetes, there are no currently approved drugs for the treatment of hearing loss. Research over the past two decades has led to a...
5.
Brahimi F, Galan A, Siegel S, Szobota S, Sarunic M, Foster A, et al.
Mol Pharmacol
. 2021 Sep;
100(5):491-501.
PMID: 34470776
The neurotrophin growth factors bind and activate two types of cell surface receptors: the tropomyosin receptor kinase (Trk) family and p75. TrkA, TrkB, and TrkC are bound preferentially by nerve...
6.
Szobota S, Mathur P, Siegel S, Black K, Saragovi H, Foster A
PLoS One
. 2019 Nov;
14(10):e0224022.
PMID: 31671109
Neurotrophins and their mimetics are potential treatments for hearing disorders because of their trophic effects on spiral ganglion neurons (SGNs) whose connections to hair cells may be compromised in many...
7.
Li Y, Yang J, Alcantara M, Abelian G, Kulkarni A, Staubli U, et al.
J Pharmacol Exp Ther
. 2018 Sep;
367(2):292-301.
PMID: 30171039
The -methyl-d-aspartate receptor coagonist d-serine is a substrate for the neutral amino acid transporters ASCT1 and ASCT2, which may regulate its extracellular levels in the central nervous system (CNS). We...
8.
Foster A, Rangel-Diaz N, Staubli U, Yang J, Penjwini M, Viswanath V, et al.
Neuropharmacology
. 2017 Aug;
126:70-83.
PMID: 28807674
The N-methyl-d-aspartate receptor (NMDA) co-agonist d-serine is a substrate for the neutral amino acid transporters ASCT1 (SLC1A4) and ASCT2 (SLC1A5). We identified l-phenylglycine (PG) and its analogs as inhibitors of...
9.
Staubli U, Rangel-Diaz N, Alcantara M, Li Y, Yang J, Zhang K, et al.
Vision Res
. 2016 Jul;
127:35-48.
PMID: 27461280
The NMDA subtype of glutamate receptor and its co-agonist d-serine play a key role in synaptic function in the central nervous system (CNS), including visual cortex and retina. In retinal...
10.
Foster A, Farnsworth J, Lind G, Li Y, Yang J, Dang V, et al.
PLoS One
. 2016 Jun;
11(6):e0156551.
PMID: 27272177
N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA receptors by synaptically released L-glutamate also requires occupancy of co-agonist binding sites in the tetrameric receptor...