Aksinya N Uvarova
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Explore the profile of Aksinya N Uvarova including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Uvarova A, Zheremyan E, Ustiugova A, Murashko M, Bogomolova E, Demin D, et al.
Int J Mol Sci
. 2024 Sep;
25(18).
PMID: 39337678
Interleukin 10 (IL10) is a major anti-inflammatory cytokine that acts as a master regulator of the immune response. A single nucleotide polymorphism rs3024505(C/T), located downstream of the gene, is associated...
2.
Uvarova A, Tkachenko E, Stasevich E, Zheremyan E, Korneev K, Kuprash D
Biochemistry (Mosc)
. 2024 Jul;
89(6):1002-1013.
PMID: 38981696
Currently, numerous associations between genetic polymorphisms and various diseases have been characterized through the Genome-Wide Association Studies. Majority of the clinically significant polymorphisms are localized in non-coding regions of the...
3.
Zheremyan E, Ustiugova A, Karamushka N, Uvarova A, Stasevich E, Bogolyubova A, et al.
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203754
Wound healing is a complex process involving a coordinated series of events aimed at restoring tissue integrity and function. Regulatory B cells (Bregs) are a subset of B lymphocytes that...
4.
Uvarova A, Stasevich E, Ustiugova A, Mitkin N, Zheremyan E, Sheetikov S, et al.
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762093
Single-nucleotide polymorphism rs71327024 located in the human 3p21.31 locus has been associated with an elevated risk of hospitalization upon SARS-CoV-2 infection. The 3p21.31 locus contains several genes encoding chemokine receptors...
5.
Zheremyan E, Ustiugova A, Uvarova A, Karamushka N, Stasevich E, Gogoleva V, et al.
Front Immunol
. 2023 Sep;
14:1178445.
PMID: 37731503
Regulatory B lymphocytes (Bregs) are B cells with well-pronounced immunosuppressive properties, allowing them to suppress the activity of effector cells. A broad repertoire of immunosuppressive mechanisms makes Bregs an attractive...
6.
Zheremyan E, Ustiugova A, Radko A, Stasevich E, Uvarova A, Mitkin N, et al.
Biochemistry (Mosc)
. 2023 Apr;
88(1):13-21.
PMID: 37068869
B lymphocytes play an important role in the regulation of immune response in both normal and pathological conditions. Traditionally, the main functions of B cells were considered to be antibody...
7.
Gorbacheva A, Uvarova A, Ustiugova A, Bhattacharyya A, Korneev K, Kuprash D, et al.
Sci Rep
. 2021 Jul;
11(1):14120.
PMID: 34239022
Transforming growth factor beta (TGF-β) is the main cytokine responsible for the induction of the epithelial-mesenchymal transition of breast cancer cells, which is a hallmark of tumor transformation to the...
8.
Korneev K, Sviriaeva E, Mitkin N, Gorbacheva A, Uvarova A, Ustiugova A, et al.
Biochim Biophys Acta Mol Basis Dis
. 2019 Dec;
1866(3):165626.
PMID: 31785408
Toll-like receptor 4 (TLR4) is an innate immunity receptor predominantly expressed on myeloid cells and involved in the development of various diseases, many of them with complex genetics. Here we...
9.
Belousov P, Afanasyeva M, Gubernatorova E, Bogolyubova A, Uvarova A, Putlyaeva L, et al.
Cancer Lett
. 2019 Jul;
467:96-106.
PMID: 31326556
Tumor-associated antigen (TAA)-specific autoantibodies have been widely implicated in cancer diagnosis. However, cancer cell lines that are typically exploited as candidate TAA sources in immunoproteomic studies may fail to accurately...
10.
Mitkin N, Muratova A, Korneev K, Pavshintsev V, Rumyantsev K, Vagida M, et al.
Biochim Biophys Acta Mol Basis Dis
. 2018 Jul;
1864(10):3211-3220.
PMID: 30006149
CD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co-stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Tregs appear to be essential suppressors of tissue-specific...