Akshaya Murugesan
Overview
Explore the profile of Akshaya Murugesan including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
137
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Recent Articles
1.
Murugesan A, Smirnov A, Alonso A, Buccioni M, Cui C, Dal Ben D, et al.
Eur J Pharm Sci
. 2025 Feb;
207:107039.
PMID: 39938810
Adenosine, a pervasive signaling molecule mediated by its interaction with G-protein-coupled receptor subtypes, especially the A adenosine receptor (AAR), plays a crucial role in cancer treatment. Recently, AAR targeting adenosine...
2.
Koochakkhani S, Branco D, Alonso A, Murugesan A, Sarkar P, Caires C, et al.
Eur J Pharm Sci
. 2024 Jun;
200:106842.
PMID: 38936514
Current treatment for Glioblastoma Multiforme (GBM) is not efficient due to its aggressive nature, tendency to infiltrate surrounding brain tissue, and chemotherapy resistance. Tetrahydroquinoline scaffolds are emerging as a new...
3.
Shoaib M, Murugesan A, Devanesan S, Alsalhi M, Kandhavelu M
Int J Biol Macromol
. 2024 May;
270(Pt 2):132457.
PMID: 38772467
Transcriptional events play a crucial role in major cellular processes that specify the activity of an individual cells and influences cell population behavior in response to environment. Active (ON) and...
4.
Murugesan A, Alshagrawi R, Thiyagarajan R, Kandhavelu M
Int J Biol Macromol
. 2024 Feb;
263(Pt 1):130262.
PMID: 38378117
Inherently identical cells exhibit significant phenotypic variation. It can be essential for many biological processes and is known to arise from stochastic, 'noisy', gene expression that is determined by intrinsic...
5.
Murugesan A, Konda Mani S, Koochakkhani S, Subramanian K, Kandhavelu J, Thiyagarajan R, et al.
Int J Biol Macromol
. 2023 Nov;
254(Pt 3):127909.
PMID: 37951450
Nerve growth factor (NGF) and its receptor, tropomyosin kinase receptor kinase type A (TrkA) is emerging as an important target for Glioblastoma (GBM) treatment. TrkA is the cancer biomarker majorly...
6.
Murugesan A, Konda Mani S, Thiyagarajan R, Palanivel S, Gurbanov A, Zubkov F, et al.
Int J Mol Sci
. 2023 Aug;
24(15).
PMID: 37569654
The tropomyosin receptor kinase A (TrkA) family of receptor tyrosine kinases (RTKs) emerge as a potential target for glioblastoma (GBM) treatment. Benzenesulfonamide analogs were identified as kinase inhibitors possessing promising...
7.
Kandhavelu J, Subramanian K, Naidoo V, Sebastianelli G, Doan P, Konda Mani S, et al.
Br J Pharmacol
. 2023 May;
181(1):107-124.
PMID: 37183661
Background And Purpose: Colorectal cancer (CRC) is the second most lethal disease, with high mortality due to its heterogeneity and chemo-resistance. Here, we have focused on the epidermal growth factor...
8.
Kari S, Kandhavelu J, Murugesan A, Thiyagarajan R, Kidambi S, Kandhavelu M
Biomed Pharmacother
. 2023 Apr;
162:114678.
PMID: 37054539
Guanine nucleotide binding protein (G protein) coupled receptor 17 (GPR17) plays crucial role in Glioblastoma multiforme (GBM) cell signaling and is primarily associated with reactive oxidative species (ROS) production and...
9.
Murugesan A, Kari S, Shrestha A, Assoah B, Saravanan K, Murugesan M, et al.
Cancers (Basel)
. 2023 Feb;
15(4).
PMID: 36831355
Glutamine metabolism is an important hallmark of several cancers with demonstrated antitumor activity in glioblastoma cancer cells (GBM). GBM cells regulate glutamine and use it as a major energy source...
10.
Konda Mani S, Thiyagarajan R, Yli-Harja O, Kandhavelu M, Murugesan A
J Cell Biochem
. 2023 Feb;
124(4):533-544.
PMID: 36791278
The human G protein coupled membrane receptor (GPR17), the sensor of brain damage, is identified as a biomarker for many neurological diseases. In human brain tissue, GPR17 exist in two...