Akshay Balsubramani
Overview
Explore the profile of Akshay Balsubramani including associated specialties, affiliations and a list of published articles.
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7
Citations
130
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Recent Articles
1.
Paloncyova M, Valerio M, Dos Santos R, Kuhrova P, Srejber M, cechova P, et al.
Mol Pharm
. 2025 Jan;
22(3):1110-1141.
PMID: 39879096
Lipid-mediated delivery of active pharmaceutical ingredients (API) opened new possibilities in advanced therapies. By encapsulating an API into a lipid nanocarrier (LNC), one can safely deliver APIs not soluble in...
2.
Li S, Moayedpour S, Li R, Bailey M, Riahi S, Kogler-Anele L, et al.
Genome Res
. 2024 Jul;
34(7):1027-1035.
PMID: 38951026
mRNA-based vaccines and therapeutics are gaining popularity and usage across a wide range of conditions. One of the critical issues when designing such mRNAs is sequence optimization. Even small proteins...
3.
Moayedpour S, Broadbent J, Riahi S, Bailey M, V Thu H, Dobchev D, et al.
Bioinformatics
. 2024 May;
40(7).
PMID: 38810107
Motivation: Lipid nanoparticles (LNPs) are the most widely used vehicles for mRNA vaccine delivery. The structure of the lipids composing the LNPs can have a major impact on the effectiveness...
4.
Nair S, Ameen M, Sundaram L, Pampari A, Schreiber J, Balsubramani A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873116
Ectopic expression of , , and (OSKM) transforms differentiated cells into induced pluripotent stem cells. To refine our mechanistic understanding of reprogramming, especially during the early stages, we profiled chromatin...
5.
Ameen M, Sundaram L, Shen M, Banerjee A, Kundu S, Nair S, et al.
Cell
. 2022 Dec;
185(26):4937-4953.e23.
PMID: 36563664
To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular development, we generated single-cell chromatin accessibility maps of human fetal heart tissues. We identified eight major differentiation trajectories involving...
6.
Schreiber J, Nair S, Balsubramani A, Kundaje A
Bioinformatics
. 2022 Jun;
38(14):3557-3564.
PMID: 35678521
Motivation: In silico saturation mutagenesis (ISM) is a popular approach in computational genomics for calculating feature attributions on biological sequences that proceeds by systematically perturbing each position in a sequence...
7.
Cochran K, Srivastava D, Shrikumar A, Balsubramani A, Hardison R, Kundaje A, et al.
Genome Res
. 2022 Jan;
32(3):512-523.
PMID: 35042722
The intrinsic DNA sequence preferences and cell type-specific cooperative partners of transcription factors (TFs) are typically highly conserved. Hence, despite the rapid evolutionary turnover of individual TF binding sites, predictive...
8.
Wainberg M, Kamber R, Balsubramani A, Meyers R, Sinnott-Armstrong N, Hornburg D, et al.
Nat Genet
. 2021 Apr;
53(5):638-649.
PMID: 33859415
A central question in the post-genomic era is how genes interact to form biological pathways. Measurements of gene dependency across hundreds of cell lines have been used to cluster genes...