Akira Ooshima
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Explore the profile of Akira Ooshima including associated specialties, affiliations and a list of published articles.
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Articles
62
Citations
1979
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Recent Articles
1.
Park S, Heo J, Mizuno S, Kim M, An H, Hong E, et al.
Metabolism
. 2023 Nov;
151:155746.
PMID: 38016540
Background: Multinucleation is a hallmark of osteoclast formation and has a unique ability to resorb bone matrix. During osteoclast differentiation, the cytoskeleton reorganization results in the generation of actin belts...
2.
Hong E, Barczak W, Park S, Heo J, Ooshima A, Munro S, et al.
Cell Death Dis
. 2023 Feb;
14(2):93.
PMID: 36765032
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal type of cancer and the third leading cause of cancer death with the lowest 5-year survival rate. Heterogeneity, difficulty in diagnosis, and...
3.
Lee J, Pang K, Kim J, Hong E, Lee J, Cho H, et al.
Nat Commun
. 2022 Oct;
13(1):6274.
PMID: 36307405
Although accumulating evidence indicates that alternative splicing is aberrantly altered in many cancers, the functional mechanism remains to be elucidated. Here, we show that epithelial and mesenchymal isoform switches of...
4.
Pang K, Lee J, Kim J, Park J, Park Y, Hong E, et al.
Cell Death Dis
. 2022 Feb;
13(2):169.
PMID: 35194034
Despite favorable responses to initial chemotherapy, drug resistance is a major cause limiting chemotherapeutic efficacy in many advanced cancers. However, mechanisms that drive drug-specific resistance in chemotherapy for patients with...
5.
Yoon C, Ahn S, Cha Y, Kim D, Bae S, Lee J, et al.
Cancers (Basel)
. 2021 Sep;
13(18).
PMID: 34572878
Few studies have examined the role of BAG2 in malignancies. We investigated the prognostic value of BAG2-expression in cancer-associated fibroblasts (CAFs) and tumor cells in predicting metastasis-free survival in patients...
6.
An H, Heo J, Kim P, Lian Z, Lee S, Park J, et al.
Cell Death Dis
. 2021 Feb;
12(2):159.
PMID: 33558527
Although tetraarsenic hexoxide is known to exert an anti-tumor effect by inducing apoptosis in various cancer cells, its effect on other forms of regulated cell death remains unclear. Here, we...
7.
Naka K, Ochiai R, Matsubara E, Kondo C, Yang K, Hoshii T, et al.
Nat Commun
. 2020 Sep;
11(1):4681.
PMID: 32943626
Although advanced lipidomics technology facilitates quantitation of intracellular lipid components, little is known about the regulation of lipid metabolism in cancer cells. Here, we show that disruption of the Gdpd3...
8.
Park Y, Pang K, Park J, Hong E, Lee J, Ooshima A, et al.
Cancer Res
. 2020 Apr;
80(12):2537-2549.
PMID: 32265222
The adaptor protein TNF receptor-associated factor 6 (TRAF6) is a key mediator in inflammation. However, the molecular mechanisms controlling its activity and stability in cancer progression remain unclear. Here we...
9.
Hong E, Park S, Ooshima A, Hong C, Park J, Heo J, et al.
Sci Rep
. 2020 Feb;
10(1):2935.
PMID: 32076068
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies. TGF-β is strongly expressed in both the epithelial and stromal compartments of PDAC, and dysregulation of TGF-β signalling is...
10.
Pang K, Park J, Ahn S, Lee J, Park Y, Ooshima A, et al.
Nat Commun
. 2019 Dec;
10(1):5805.
PMID: 31862882
The development of triple-negative breast cancer (TNBC) negatively impacts both quality of life and survival in a high percentage of patients. Here, we show that RING finger protein 208 (RNF208)...