Akinobu Okabe
Overview
Explore the profile of Akinobu Okabe including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
261
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Recent Articles
1.
Tamai E, Yoshida H, Sekiya H, Nariya H, Miyata S, Okabe A, et al.
Mol Microbiol
. 2014 Mar;
92(2):326-37.
PMID: 24674022
Gram-positive bacteria possess a thick cell wall composed of a mesh polymer of peptidoglycans, which provides physical protection. Endolysins encoded by phages infecting bacteria can hydrolyse peptidoglycans in the bacterial...
2.
Nariya H, Miyata S, Kuwahara T, Okabe A
Appl Environ Microbiol
. 2011 Oct;
77(23):8439-41.
PMID: 21965407
A xylose-inducible gene expression vector for Clostridium perfringens was developed. Plasmid pXCH contains a chromosomal region from Clostridium difficile (xylR-P(xy)(lB)): xylR, encoding the xylose repressor, xylO, the xyl operator sequence,...
3.
Nariya H, Miyata S, Tamai E, Sekiya H, Maki J, Okabe A
Appl Microbiol Biotechnol
. 2011 Apr;
90(6):1973-9.
PMID: 21484204
Clostridium perfringens produces potent toxins and histolytic enzymes, causing various diseases including life-threatening fulminant diseases in humans and other animals. Aiming at utilizing a phage endolysin as a therapeutic alternative...
4.
Nariya H, Miyata S, Suzuki M, Tamai E, Okabe A
Appl Environ Microbiol
. 2010 Dec;
77(4):1375-82.
PMID: 21183644
Many pathogenic clostridial species produce toxins and enzymes. To facilitate genome-wide identification of virulence factors and biotechnological application of their useful products, we have developed a markerless in-frame deletion method...
5.
Tanaka H, Nariya H, Suzuki M, Houchi H, Tamai E, Miyata S, et al.
Protein Expr Purif
. 2010 Oct;
76(1):83-9.
PMID: 20940055
Clostripain (CLO) produced by Clostridium histolyticum is an arginine-specific endopeptidase with the potential for applicability to diverse medical and industrial uses. In this study, we developed an expression system allowing...
6.
Manabe S, Nariya H, Miyata S, Tanaka H, Minami J, Suzuki M, et al.
Microbiology (Reading)
. 2009 Oct;
156(Pt 2):561-569.
PMID: 19850615
Clostridium perfringens produces a homologue of clostripain (Clo), the arginine-specific endopeptidase of Clostridium histolyticum. To determine the biochemical and biological properties of the C. perfringens homologue (Clp), it was purified...
7.
Tamai E, Miyata S, Tanaka H, Nariya H, Suzuki M, Matsushita O, et al.
Appl Microbiol Biotechnol
. 2008 Jul;
80(4):627-35.
PMID: 18629492
Clostridium histolyticum collagenase is used to isolate cells from various organs and tissues for tissue engineering, and also to treat destructive fibrosis; thus, the demand for high-grade enzyme preparations is...
8.
Tanaka H, Tamai E, Miyata S, Taniguchi Y, Nariya H, Hatano N, et al.
Appl Microbiol Biotechnol
. 2007 Oct;
77(5):1063-71.
PMID: 17965858
The inherent difficulty of expressing clostridial AT-rich genes in a heterologous host has limited their biotechnological application. We previously reported a plasmid for high-level expression of clostridial genes in Clostridium...
9.
Tanaka H, Asakura M, Doi C, Fukuoka N, Tamai E, Miyata S, et al.
Yakugaku Zasshi
. 2006 Sep;
126(9):805-9.
PMID: 16946594
Levocarnitine chloride is used for the therapeutic purpose of levocarnitine deficiency. For infants, however, levocarnitine chloride tablets must be crushed to avoid difficulties associated with swallowing, and also to administer...
10.
Shimamoto S, Tamai E, Matsushita O, Minami J, Okabe A, Miyata S
Microbiol Immunol
. 2005 Mar;
49(3):245-53.
PMID: 15781998
Epsilon-toxin (ET) of Clostridium perfringens, which causes fatal enterotoxemia in ungulates, was previously shown to bind to and form a heptameric pore within the detergent-resistant membranes (DRMs) of MDCK cells....