Ajay S Yekkirala
Overview
Explore the profile of Ajay S Yekkirala including associated specialties, affiliations and a list of published articles.
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10
Citations
339
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Recent Articles
1.
Sprague J, Yekkirala A, Singh B, Tochitsky I, Stephens M, Viramontes O, et al.
Commun Biol
. 2023 Dec;
6(1):1228.
PMID: 38052846
TRPV1 is an ion channel that transduces noxious heat and chemical stimuli and is expressed in small fiber primary sensory neurons that represent almost half of skin nerve terminals. Tissue...
2.
Yekkirala A, Roberson D, Bean B, Woolf C
Nat Rev Drug Discov
. 2017 Oct;
16(11):810.
PMID: 28983099
This corrects the article DOI: 10.1038/nrd.2017.87.
3.
Yekkirala A, Roberson D, Bean B, Woolf C
Nat Rev Drug Discov
. 2017 Jun;
16(8):545-564.
PMID: 28596533
Acute and chronic pain complaints, although common, are generally poorly served by existing therapies. This unmet clinical need reflects a failure to develop novel classes of analgesics with superior efficacy,...
4.
Sisignano M, Angioni C, Park C, Meyer Dos Santos S, Jordan H, Kuzikov M, et al.
Proc Natl Acad Sci U S A
. 2016 Nov;
113(44):12544-12549.
PMID: 27791151
Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose- and therapy-limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we report increased expression of the...
5.
Yekkirala A, Kalyuzhny A, Portoghese P
ACS Chem Biol
. 2013 May;
8(7):1412-6.
PMID: 23675763
Bivalent ligands that contain two pharmacophores linked by a spacer are promising tools to investigate the pharmacology of opioid receptor heteromers. Evidence for occupation of neighboring protomers by two phamacophores...
6.
Yekkirala A, Banks M, Lunzer M, Negus S, Rice K, Portoghese P
ACS Chem Neurosci
. 2012 Sep;
3(9):720-7.
PMID: 23019498
Morphine and related drugs are widely employed as analgesics despite the side effects associated with their use. Although morphine is thought to mediate analgesia through mu opioid receptors, delta opioid...
7.
Metcalf M, Yekkirala A, Powers M, Kitto K, Fairbanks C, Wilcox G, et al.
ACS Chem Neurosci
. 2012 Aug;
3(7):505-9.
PMID: 22860219
Coexpressed and colocalized μ- and δ-opioid receptors have been established to exist as heteromers in cultured cells and in vivo. However the biological significance of opioid receptor heteromer activation is...
8.
Yekkirala A, Kalyuzhny A, Portoghese P
ACS Chem Neurosci
. 2012 Jul;
1(2):146-54.
PMID: 22816017
Research in the opioid field has relied heavily on the use of standard agonist ligands such as morphine, [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin (DAMGO), U69593, bremazocine, [d-Pen(2)d-Pen(5)]enkephalin (DPDPE), and deltorphin-II as tools for investigating...
9.
Yekkirala A
Life Sci
. 2012 Jul;
92(8-9):438-45.
PMID: 22771696
G protein coupled receptors (GPCRs) represent the largest family of cell surface receptors that are involved in regulating several physiological and behavioral responses in organisms. Indeed, over half of all...
10.
Yekkirala A, Lunzer M, McCurdy C, Powers M, Kalyuzhny A, Roerig S, et al.
Proc Natl Acad Sci U S A
. 2011 Mar;
108(12):5098-103.
PMID: 21385944
Numerous G protein-coupled receptors (GPCRs) have been shown to form heteromeric receptors in cell-based assays. Among the many heteromers reported in the opioid receptor family are μ/κ, κ/δ, and μ/δ....