Aiyun Wen
Overview
Explore the profile of Aiyun Wen including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
481
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0
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Recent Articles
1.
Weeden T, Picariello T, Quinn B, Spring S, Shen P, Qiu Q, et al.
Commun Med (Lond)
. 2025 Jan;
5(1):22.
PMID: 39827287
Background: We developed the FORCE platform to overcome limitations of oligonucleotide delivery to muscle and enable their applicability to neuromuscular disorders. The platform consists of an antigen-binding fragment, highly specific...
2.
Lee E, Chan S, Lee Y, Polacheck W, Kwak S, Wen A, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(41):e2308941120.
PMID: 37782785
Impaired lymphatic drainage and lymphedema are major morbidities whose mechanisms have remained obscure. To study lymphatic drainage and its impairment, we engineered a microfluidic culture model of lymphatic vessels draining...
3.
Desjardins C, Yao M, Hall J, ODonnell E, Venkatesan R, Spring S, et al.
Nucleic Acids Res
. 2022 Aug;
50(20):11401-11414.
PMID: 35944903
Current therapies for Duchenne muscular dystrophy (DMD) use phosphorodiamidate morpholino oligomers (PMO) to induce exon skipping in the dystrophin pre-mRNA, enabling the translation of a shortened but functional dystrophin protein....
4.
Song K, Cai X, Dong Y, Wu H, Wei Y, Shankavaram U, et al.
J Clin Invest
. 2020 Sep;
131(1).
PMID: 32960814
Estrogen receptor-negative (ER-negative) breast cancer is thought to be more malignant and devastating than ER-positive breast cancer. ER-negative breast cancer exhibits elevated NF-κB activity, but how this abnormally high NF-κB...
5.
Dong Y, Lee Y, Cui K, He M, Wang B, Bhattacharjee S, et al.
Nat Commun
. 2020 Aug;
11(1):3984.
PMID: 32770009
The epsin family of endocytic adapter proteins are widely expressed, and interact with both proteins and lipids to regulate a variety of cell functions. However, the role of epsins in...
6.
Brophy M, Dong Y, Tao H, Yancey P, Song K, Zhang K, et al.
Circ Res
. 2019 Jan;
124(4):e6-e19.
PMID: 30595089
Rationale: Atherosclerosis is, in part, caused by immune and inflammatory cell infiltration into the vascular wall, leading to enhanced inflammation and lipid accumulation in the aortic endothelium. Understanding the molecular...
7.
Wu H, Rahman H, Dong Y, Liu X, Lee Y, Wen A, et al.
J Clin Invest
. 2018 Aug;
128(9):4025-4043.
PMID: 30102256
Impaired lymphangiogenesis is a complication of chronic complex diseases, including diabetes. VEGF-C/VEGFR3 signaling promotes lymphangiogenesis, but how this pathway is affected in diabetes remains poorly understood. We previously demonstrated that...
8.
Dong Y, Fernandes C, Liu Y, Wu Y, Wu H, Brophy M, et al.
Diab Vasc Dis Res
. 2016 Dec;
14(1):14-23.
PMID: 27941052
It is well established that diabetes mellitus accelerates atherosclerotic vascular disease. Endothelial injury has been proposed to be the initial event in the pathogenesis of atherosclerosis. Endothelium not only acts...
9.
Song K, Wu H, Rahman H, Dong Y, Wen A, Brophy M, et al.
Cell Mol Life Sci
. 2016 Aug;
74(3):393-398.
PMID: 27572288
VEGF-driven tumor angiogenesis has been validated as a central target in several tumor types deserving of continuous and further considerations to improve the efficacy and selectivity of the current therapeutic...
10.
Rahman H, Wu H, Dong Y, Pasula S, Wen A, Sun Y, et al.
Circ Res
. 2016 Feb;
118(6):957-969.
PMID: 26879230
Rationale: We previously reported that vascular endothelial growth factor (VEGF)-induced binding of VEGF receptor 2 (VEGFR2) to epsins 1 and 2 triggers VEGFR2 degradation and attenuates VEGF signaling. The epsin...