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Aixa V Morales

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Articles 20
Citations 771
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Recent Articles
1.
Tenorio-Castano J, Gomez A, Coronado M, Rodriguez-Martin P, Parra A, Pascual P, et al.
Clin Genet . 2023 Sep; 104(6):637-647. PMID: 37702321
Lamb-Shaffer Syndrome (LSS; OMIM #616803; ORPHA #313892; ORPHA #313884) is an infrequent genetic disorder that affects multiple aspects of human development especially those related to the development of the nervous...
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Li L, Medina-Menendez C, Garcia-Corzo L, Cordoba-Beldad C, Quiroga A, Calleja Barca E, et al.
Cell Rep . 2022 Feb; 38(5):110313. PMID: 35108528
The adult neurogenic niche in the hippocampus is maintained through activation of reversibly quiescent neural stem cells (NSCs) with radial glia-like morphology (RGLs). Here, we show that the expression of...
3.
Cid E, Marquez-Galera A, Valero M, Gal B, Medeiros D, Navarron C, et al.
Cell Rep . 2021 Jun; 35(10):109229. PMID: 34107264
Hippocampal sclerosis, the major neuropathological hallmark of temporal lobe epilepsy, is characterized by different patterns of neuronal loss. The mechanisms of cell-type-specific vulnerability and their progression and histopathological classification remain...
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Zaldivar-Diez J, Li L, Garcia A, Zhao W, Medina-Menendez C, Haggarty S, et al.
J Med Chem . 2019 Dec; 63(5):2638-2655. PMID: 31825616
Leucine rich repeat kinase 2 (LRRK2) is an enigmatic enzyme and a relevant target for Parkinson's disease (PD). However, despite the significant amount of research done in the past decade,...
6.
Morales A, Mira H
Front Cell Dev Biol . 2019 Jun; 7:96. PMID: 31214589
The generation of new neurons is a lifelong process in many vertebrate species that provides an extra level of plasticity to several brain circuits. Frequently, neurogenesis in the adult brain...
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Uliassi E, Pena-Altamira L, Morales A, Massenzio F, Petralla S, Rossi M, et al.
ACS Chem Neurosci . 2018 Sep; 10(1):279-294. PMID: 30253086
Overcoming the lack of effective treatments and the continuous clinical trial failures in neurodegenerative drug discovery might require a shift from the prevailing paradigm targeting pathogenesis to the one targeting...
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Palencia-Campos A, Ullah A, Nevado J, Yildirim R, Unal E, Ciorraga M, et al.
Hum Mol Genet . 2017 Oct; 26(23):4556-4571. PMID: 28973407
GLI1, GLI2 and GLI3 form a family of transcription factors which regulate development by mediating the action of Hedgehog (Hh) morphogens. Accordingly, inactivating variants in GLI2 and GLI3 are found...
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Salado I, Zaldivar-Diez J, Sebastian-Perez V, Li L, Geiger L, Gonzalez S, et al.
Eur J Med Chem . 2017 Jul; 138:328-342. PMID: 28688273
Leucine-rich repeat kinase 2 (LRRK2) is one of the most pursued targets for Parkinson's disease (PD) therapy. Moreover, it has recently described its role in regulating Wnt signaling and thus,...
10.
Diez Del Corral R, Morales A
Front Cell Dev Biol . 2017 Jun; 5:58. PMID: 28626748
During vertebrate embryonic development, the spinal cord is formed by the neural derivatives of a neuromesodermal population that is specified at early stages of development and which develops in concert...