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Aishwarya Nene

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Articles 7
Citations 434
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Recent Articles
1.
Earland N, Zhang W, Usmani A, Nene A, Bacchiocchi A, Chen D, et al.
Immunol Rev . 2023 Jul; 318(1):96-109. PMID: 37491734
Immune-related toxicities, otherwise known as immune-related adverse events (irAEs), occur in a substantial fraction of cancer patients treated with immune checkpoint inhibitors (ICIs). Ranging from asymptomatic to life-threatening, ICI-induced irAEs...
2.
Nene A, Hong C, McGuone D, Matouk C, Omay S
J Neurosurg Case Lessons . 2022 Sep; 3(10). PMID: 36130536
Background: Intracranial aneurysms and pituitary adenomas are relatively common pathologies that, in rare instances, may concurrently present. Their management poses considerable clinical and technical challenges. Observations: The authors present a...
3.
Bell R, Castellana-Cruz M, Nene A, Thrush R, Xu C, Kumita J, et al.
J Mol Biol . 2022 Sep; 435(1):167825. PMID: 36099961
Mutations in the SNCA gene, which encodes the protein α-synuclein, have been linked with early onset Parkinson's disease. The exact nature of this association, however, is still poorly understood. To...
4.
Bell R, Thrush R, Castellana-Cruz M, Oeller M, Staats R, Nene A, et al.
Biochemistry . 2022 Aug; 61(17):1743-1756. PMID: 35944093
Parkinson's disease is associated with the aberrant aggregation of α-synuclein. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play a modulatory role....
5.
Lozano A, Chaudhuri A, Nene A, Bacchiocchi A, Earland N, Vesely M, et al.
Nat Med . 2022 Jan; 28(2):353-362. PMID: 35027754
Severe immune-related adverse events (irAEs) occur in up to 60% of patients with melanoma treated with immune checkpoint inhibitors (ICIs). However, it is unknown whether a common baseline immunological state...
6.
Bershteyn M, Nowakowski T, Pollen A, Di Lullo E, Nene A, Wynshaw-Boris A, et al.
Cell Stem Cell . 2017 Jan; 20(4):435-449.e4. PMID: 28111201
Classical lissencephaly is a genetic neurological disorder associated with mental retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe form of the disease. In this study, to...
7.
Nene A, Chen C, Disatnik M, Cruz L, Mochly-Rosen D
J Biomed Sci . 2017 Jan; 24(1):3. PMID: 28056995
Background: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a key enzyme for the metabolism of many toxic aldehydes such as acetaldehyde, derived from alcohol drinking, and 4HNE, an oxidative stress-derived lipid...