Janet R Kumita
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Explore the profile of Janet R Kumita including associated specialties, affiliations and a list of published articles.
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87
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2404
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Recent Articles
1.
Sneideriene G, Czekalska M, Xu C, Jayaram A, Krainer G, Arter W, et al.
ACS Nano
. 2024 Jun;
18(27):17469-17482.
PMID: 38916260
Parkinson's disease (PD) is an increasingly prevalent and currently incurable neurodegenerative disorder linked to the accumulation of α-synuclein (αS) protein aggregates in the nervous system. While αS binding to membranes...
2.
Banerjee A, Mathew S, Naqvi M, Yilmaz S, Zacharopoulou M, Doruker P, et al.
Sci Adv
. 2024 May;
10(22):eadn2208.
PMID: 38820156
PR65 is the HEAT repeat scaffold subunit of the heterotrimeric protein phosphatase 2A (PP2A) and an archetypal tandem repeat protein. Its conformational mechanics plays a crucial role in PP2A function...
3.
Probing the effects of N-terminal acetylation on α-synuclein structure, aggregation and cytotoxicity
Bell R, Vendruscolo M, Kumita J
Methods Enzymol
. 2023 Aug;
686:45-65.
PMID: 37532408
Parkinson's disease is associated with the aberrant aggregation of α-synuclein within brain cells. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play...
4.
Hutin S, Kumita J, Strotmann V, Dolata A, Ling W, Louafi N, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(28):e2304714120.
PMID: 37399408
Liquid-liquid phase separation (LLPS) is an important mechanism enabling the dynamic compartmentalization of macromolecules, including complex polymers such as proteins and nucleic acids, and occurs as a function of the...
5.
Manucat-Tan N, Chowdhury A, Cataldi R, Abdullah R, Kumita J, Wyatt A
Redox Biol
. 2023 Jun;
:102768.
PMID: 37301666
No abstract available.
6.
Manucat-Tan N, Chowdhury A, Cataldi R, Abdullah R, Kumita J, Wyatt A
Redox Biol
. 2023 May;
63:102736.
PMID: 37216700
Exacerbated hypochlorite (OCl) production is linked to neurodegenerative processes, but there is growing evidence that lower levels of hypochlorite activity are important to protein homeostasis. In this study we characterise...
7.
Bell R, Castellana-Cruz M, Nene A, Thrush R, Xu C, Kumita J, et al.
J Mol Biol
. 2022 Sep;
435(1):167825.
PMID: 36099961
Mutations in the SNCA gene, which encodes the protein α-synuclein, have been linked with early onset Parkinson's disease. The exact nature of this association, however, is still poorly understood. To...
8.
Bell R, Thrush R, Castellana-Cruz M, Oeller M, Staats R, Nene A, et al.
Biochemistry
. 2022 Aug;
61(17):1743-1756.
PMID: 35944093
Parkinson's disease is associated with the aberrant aggregation of α-synuclein. Although the causes of this process are still unclear, post-translational modifications of α-synuclein are likely to play a modulatory role....
9.
Xu C, Castellana-Cruz M, Chen S, Du Z, Meisl G, Levin A, et al.
Molecules
. 2022 Feb;
27(4).
PMID: 35209093
A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related...
10.
Cao Y, Adamcik J, Diener M, Kumita J, Mezzenga R
J Am Chem Soc
. 2021 Jul;
143(30):11473-11481.
PMID: 34286587
The propensity to self-assemble into amyloid fibrils with a shared cross-β architecture is a generic feature of proteins. Amyloid-related diseases affect millions of people worldwide, yet they are incurable and...