Ainoleena Turku
Overview
Explore the profile of Ainoleena Turku including associated specialties, affiliations and a list of published articles.
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22
Citations
192
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Recent Articles
1.
Kalliokoski T, Turku A, Kasnanen H
J Chem Inf Model
. 2024 Dec;
65(1):125-132.
PMID: 39710946
Given the size of the relevant chemical space for drug discovery, working with fully enumerated compound libraries (especially in three-dimensional (3D)) is unfeasible. Nonenumerated virtual chemical spaces are a practical...
2.
Leino T, Turku A, Urvas L, Adhikari K, Oksanen J, Steynen Y, et al.
Bioorg Med Chem
. 2023 May;
88-89:117325.
PMID: 37209639
Azulene is a rare ring structure in drugs, and we investigated whether it could be used as a biphenyl mimetic in known orexin receptor agonist Nag 26, which is binding...
3.
Kowalski-Jahn M, Schihada H, Turku A, Huber T, Sakmar T, Schulte G
Sci Adv
. 2021 Nov;
7(46):eabj7917.
PMID: 34757789
Frizzleds (FZD) are G protein–coupled receptors containing an extracellular cysteine-rich domain (CRD) binding Wingless/Int-1 lipoglycoproteins (WNTs). Despite the role of WNT/FZD signaling in health and disease, our understanding of how...
4.
Zhou Y, Arribas G, Turku A, Jurgenson T, Mkrtchian S, Krebs K, et al.
Sci Adv
. 2021 Sep;
7(36):eabi6856.
PMID: 34516913
Interindividual variability in drug response constitutes a major concern in pharmacotherapy. While polymorphisms in genes involved in drug disposition have been extensively studied, drug target variability remains underappreciated. By mapping...
5.
Xu L, Chen B, Schihada H, Wright S, Turku A, Wu Y, et al.
Cell Res
. 2021 Jul;
31(12):1311-1314.
PMID: 34239071
No abstract available.
6.
Turku A, Schihada H, Kozielewicz P, Bowin C, Schulte G
Nat Commun
. 2021 Jun;
12(1):3919.
PMID: 34168128
The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD) subtypes and Smoothened (SMO), remains one of the most enigmatic GPCR families. While SMO relies on cholesterol...
7.
Schihada H, Kowalski-Jahn M, Turku A, Schulte G
Biosens Bioelectron
. 2021 Jan;
177:112948.
PMID: 33486136
The G protein-coupled receptors Frizzled (FZD) act as molecular checkpoints mediating intracellular signaling induced by 19 mammalian, secreted Wingless/Int-1 lipoglycoproteins (WNTs). Despite the vital roles of these signaling components in...
8.
Johansson N, Turku A, Vidilaseris K, Dreano L, Khattab A, Ayuso Perez D, et al.
ACS Med Chem Lett
. 2020 Apr;
11(4):605-610.
PMID: 32292570
Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in . malaria. Yet only few nonphosphorus inhibitors have been reported...
9.
Kozielewicz P, Turku A, Bowin C, Petersen J, Valnohova J, Canizal M, et al.
Nat Commun
. 2020 Jan;
11(1):414.
PMID: 31964872
WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell regulation and tissue homeostasis. FZDs are linked to severe human pathology and are seen as a promising target...
10.
Vidilaseris K, Johansson N, Turku A, Kiriazis A, Gennas G, Yli-Kauhaluoma J, et al.
J Vis Exp
. 2019 Dec;
(153).
PMID: 31814619
Membrane-bound pyrophosphatases (mPPases) are dimeric enzymes that occur in bacteria, archaea, plants, and protist parasites. These proteins cleave pyrophosphate into two orthophosphate molecules, which is coupled with proton and/or sodium...