Aili L Lazaar
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Explore the profile of Aili L Lazaar including associated specialties, affiliations and a list of published articles.
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38
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1238
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Recent Articles
1.
Mekontso Dessap A, Hanrott K, Powley W, Fowler A, Bayliffe A, Bagate F, et al.
J Clin Med
. 2022 Aug;
11(15).
PMID: 35955981
Background: Right ventricular () dysfunction is associated with pulmonary vasoconstriction in mechanically ventilated patients. Enhancing the activity of angiotensin-converting enzyme 2 (2), a key enzyme of the renin-angiotensin system (),...
2.
Simon M, Hanrott K, Budd D, Torres F, Grunig E, Escribano-Subias P, et al.
Pulm Circ
. 2022 May;
12(1):e12024.
PMID: 35506108
Preclinical and early clinical studies suggest that angiotensin-converting enzyme type 2 activity may be impaired in patients with pulmonary arterial hypertension (PAH); therefore, administration of exogenous angiotensin-converting enzyme type 2...
3.
Hall D, Hanrott K, Badorrek P, Berliner D, Budd D, Eames R, et al.
Pulm Ther
. 2021 Jun;
7(2):487-501.
PMID: 34189703
Introduction: Angiotensin-converting enzyme 2 (ACE2) is a key enzyme of the renin-angiotensin system (RAS) that has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). Enhancing ACE2 activity...
4.
Keir H, Richardson H, Fillmore C, Shoemark A, Lazaar A, Miller B, et al.
ERJ Open Res
. 2020 Dec;
6(4).
PMID: 33263062
https://bit.ly/32SeisO.
5.
Mole S, Harry A, Fowler A, Hotee S, Warburton J, Waite S, et al.
Pulm Pharmacol Ther
. 2020 Nov;
64:101977.
PMID: 33189900
Background: Acute Respiratory Distress Syndrome (ARDS) is associated with increased pulmonary-vascular permeability. In the lung, transient receptor potential vanilloid 4 (TRPV4), a Ca-permeable cation channel, is a regulator of endothelial...
6.
Stott-Miller M, Mullerova H, Miller B, Tabberer M, El Baou C, Keeley T, et al.
Int J Chron Obstruct Pulmon Dis
. 2020 Oct;
15:2467-2476.
PMID: 33116463
Background: Chronic cough and phlegm are frequently reported chronic obstructive pulmonary disease (COPD) symptoms. Prior research classified chronic mucus hypersecretion (CMH) based on the presence of these symptoms for ≥3...
7.
Lazaar A, Miller B, Donald A, Keeley T, Ambery C, Russell J, et al.
Respir Res
. 2020 Jun;
21(1):149.
PMID: 32532258
Background: Oral CXC chemokine receptor 2 (CXCR2) antagonists have been shown to inhibit neutrophil migration and activation in the lung in preclinical and human models of neutrophilic airway inflammation. A...
8.
Ryan J, Bayliffe A, McAuley D, Yeung J, Thickett D, Howells P, et al.
Eur J Anaesthesiol
. 2020 May;
37(11):1014-1024.
PMID: 32467417
Background: Tumour necrosis factor receptor 1 (TNFR1) signalling mediates the cell death and inflammatory effects of TNF-α. Objective: The current clinical trial investigated the effects of a nebulised TNFR1 antagonist...
9.
Anderson B, Calfee C, Liu K, Reilly J, Kangelaris K, Shashaty M, et al.
Crit Care
. 2019 Dec;
23(1):400.
PMID: 31818332
Background: Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8),...
10.
Iida T, Matsuzawa Y, Ogura H, Nagakubo T, Wakamatsu A, Ambery C, et al.
Clin Pharmacol Drug Dev
. 2019 May;
8(8):1081-1087.
PMID: 31056840
Danirixin is a selective and reversible CXC chemokine receptor 2 antagonist that may be useful for the treatment of respiratory diseases such as chronic obstructive pulmonary disease. This study aimed...