Aidan J Hampson
Overview
Explore the profile of Aidan J Hampson including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
246
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0
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Recent Articles
1.
Chiang Y, Berthold E, Kuntz M, Kanumuri S, Senetra A, Mukhopadhyay S, et al.
ACS Pharmacol Transl Sci
. 2024 Aug;
7(8):2452-2464.
PMID: 39144552
This study reports the steady-state pharmacokinetic parameters for mitragynine and characterizes its elimination in male and female rats. Four male and female rats were dosed q12h with 40 mg/kg, and...
2.
Obeng S, Crowley M, Mottinelli M, Leon F, Zuarth Gonzalez J, Chen Y, et al.
Eur J Pharmacol
. 2024 Jul;
980:176863.
PMID: 39068978
Mitragynine, an alkaloid present in the leaves of Mitragyna speciosa (kratom), has a complex pharmacology that includes low efficacy agonism at μ-opioid receptors (MORs). This study examined the activity of...
3.
Lee D, Schlienz N, Herrmann E, Martin E, Leoutsakos J, Budney A, et al.
J Subst Use Addict Treat
. 2023 Oct;
156:209180.
PMID: 37802317
Background: Sleep disturbance is commonly reported among individuals meeting criteria for cannabis use disorder (CUD), and people who use cannabis frequently report sleep disturbance as a contributor to failed quit...
4.
Chambers L, Hallowell B, Zullo A, Paiva T, Berk J, Gaither R, et al.
JAMA Netw Open
. 2023 Sep;
6(9):e2334540.
PMID: 37721749
Importance: Buprenorphine treatment for opioid use disorder (OUD) has more than doubled since 2009. However, current US Food and Drug Administration buprenorphine dosing guidelines are based on studies among people...
5.
Leon F, Obeng S, Mottinelli M, Chen Y, King T, Berthold E, et al.
J Med Chem
. 2021 Sep;
64(18):13510-13523.
PMID: 34467758
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we investigated the in vitro and in...
6.
Chear N, Leon F, Sharma A, Kanumuri S, Zwolinski G, Abboud K, et al.
J Nat Prod
. 2021 Feb;
84(4):1034-1043.
PMID: 33635670
Ten indole and oxindole alkaloids (-) were isolated from the freshly collected leaves of Malaysian (Kratom). The chemical structures of these compounds were established on the basis of extensive 1D...
7.
Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy
Kamble S, Leon F, King T, Berthold E, Lopera-Londono C, Raju K, et al.
ACS Pharmacol Transl Sci
. 2020 Dec;
3(6):1063-1068.
PMID: 33344889
Kratom is widely consumed in the United States for self-treatment of pain and opioid withdrawal symptoms. Mitragynine is the most abundant alkaloid in kratom and is a μ-opioid receptor agonist....
8.
Hampson A, Schroeder J, Ellefsen K, Yammine L, Epstein D, Preston K, et al.
Clin Pharmacol Ther
. 2020 Jun;
108(6):1203-1212.
PMID: 32496573
Adherence monitoring is a vital component of clinical efficacy trials, as the regularity of medication consumption affects both efficacy and adverse effect profiles. Pill-counts do not confirm consumption, and invasive...
9.
Klein B, Jacobson C, Metcalf C, Smith M, Wilcox K, Hampson A, et al.
Neurochem Res
. 2017 May;
42(7):1939-1948.
PMID: 28478594
Cannabidiol (CBD) is a cannabinoid component of marijuana that has no significant activity at cannabinoid receptors or psychoactive effects. There is considerable interest in CBD as a therapy for epilepsy....
10.
Volkow N, Hampson A, Baler R
Annu Rev Pharmacol Toxicol
. 2016 Sep;
57:285-308.
PMID: 27618739
Cannabis enables and enhances the subjective sense of well-being by stimulating the endocannabinoid system (ECS), which plays a key role in modulating the response to stress, reward, and their interactions....