Aidan E Gilchrist
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Explore the profile of Aidan E Gilchrist including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
83
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Recent Articles
1.
Liu Y, Gilchrist A, Heilshorn S
Adv Mater
. 2024 Sep;
36(45):e2407794.
PMID: 39233559
The biochemical and biophysical properties of the extracellular matrix (ECM) play a pivotal role in regulating cellular behaviors such as proliferation, migration, and differentiation. Engineered protein-based hydrogels, with highly tunable...
2.
LeSavage B, Zhang D, Huerta-Lopez C, Gilchrist A, Krajina B, Karlsson K, et al.
Nat Mater
. 2024 Jul;
23(8):1138-1149.
PMID: 38965405
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes to the PDAC tumour phenotype has been difficult to dissect....
3.
Thompson G, Gilchrist A, Lam V, Nunes A, Payan B, Mora-Boza A, et al.
J Biomed Mater Res A
. 2024 Jun;
112(12):2124-2135.
PMID: 38894666
Hematopoietic stem cells (HSCs) are the apical cells of the hematopoietic system, giving rise to cells of the blood and lymph lineages. HSCs reside primarily within bone marrow niches that...
4.
de Paiva Narciso N, Navarro R, Gilchrist A, Trigo M, Aviles Rodriguez G, Heilshorn S
Adv Healthc Mater
. 2023 Jun;
12(27):e2301265.
PMID: 37389811
Dynamic covalent chemistry (DCC) crosslinks can form hydrogels with tunable mechanical properties permissive to injectability and self-healing. However, not all hydrogels with transient crosslinks are easily extrudable. For this reason,...
5.
Pastrana-Otero I, Majumdar S, Gilchrist A, Harley B, Kraft M
Anal Chem
. 2022 Aug;
94(35):11999-12007.
PMID: 36001072
Efforts to expand hematopoietic stem and progenitor cells (HSPCs) in vitro are motivated by their use in the treatment of leukemias and other blood and immune system diseases. The combinations...
6.
Ngo M, Barnhouse V, Gilchrist A, Mahadik B, Hunter C, Hensold J, et al.
Adv Funct Mater
. 2022 May;
31(51).
PMID: 35558090
Biomaterials that replicate patterns of microenvironmental signals from the stem cell niche offer the potential to refine platforms to regulate stem cell behavior. While significant emphasis has been placed on...
7.
Gilchrist A, Harley B
Adv Healthc Mater
. 2021 Dec;
11(7):e2102130.
PMID: 34936239
Hematopoietic stem cells are the progenitors of the blood and immune system and represent the most widely used regenerative therapy. However, their rarity and limited donor base necessitate the design...
8.
Gilchrist A, Serrano J, Ngo M, Hrnjak Z, Kim S, Harley B
Acta Biomater
. 2021 Jun;
131:138-148.
PMID: 34161871
Biomaterial platforms are an integral part of stem cell biomanufacturing protocols. The collective biophysical, biochemical, and cellular cues of the stem cell niche microenvironment play an important role in regulating...
9.
Pastrana-Otero I, Majumdar S, Gilchrist A, Gorman B, Harley B, Kraft M
Analyst
. 2020 Oct;
145(21):7030-7039.
PMID: 33103665
Biomaterial microarrays are being developed to facilitate identifying the extrinsic cues that elicit stem cell fate decisions to self-renew, differentiate and remain quiescent. Raman microspectroscopy, often combined with multivariate analysis...
10.
Gilchrist A, Harley B
Integr Biol (Camb)
. 2020 Jun;
12(7):175-187.
PMID: 32556172
Hematopoietic stem cells (HSCs) primarily reside in the bone marrow, where they receive external cues from their local microenvironment. The complex milieu of biophysical cues, cellular components and cell-secreted factors...