Ahmed M El Kerdawy
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Explore the profile of Ahmed M El Kerdawy including associated specialties, affiliations and a list of published articles.
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Articles
54
Citations
348
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Recent Articles
1.
Temirak A, El Kerdawy A, Nageeb A, Abdel-Mohsen H
BMC Chem
. 2025 Feb;
19(1):45.
PMID: 39985108
A new series of 1-substiuted-5,6-dichloro-2-(4-methoxyphenyl)-1H-benzo[d]imidazoles 10a-p was designed and synthesized to target both BRAF and BRAF. The design strategy ensures that these derivatives would effectively occupy the ATP binding pocket...
2.
Abd El-Haleem A, Kassem M, Elnagar M, Abbas S, El Kerdawy A, Farouk A
ACS Med Chem Lett
. 2024 Dec;
15(12):2150-2157.
PMID: 39691520
New derivatives -, , -, -, , , , -, -, and were synthesized and evaluated for their VEGFR-2 inhibition. Compounds , , and showed remarkable enzyme inhibition IC =...
3.
Hassan S, Zaater M, Abdel-Rahman I, Ibrahim E, El Kerdawy A, Abouelmagd S
Int J Pharm
. 2024 Nov;
667(Pt B):124893.
PMID: 39515673
The development of new forms of existing APIs with enhanced physicochemical properties is critical for improving their therapeutic potential. In this context, ionic liquids (ILs) and deep eutectic solvents (DESs)...
4.
Ghannam I, El Kerdawy A, Mounier M, Abo-Elfadl M, Abdel-Mohsen H
Bioorg Chem
. 2024 Oct;
153:107848.
PMID: 39368145
In the current study, a novel series of diaryl urea incorporating oxindole moiety was rationally designed as type II BRAF inhibitors targeting BRAF and KRAS mutant cancers. Molecular hybridization between...
5.
Eldehna W, Habib Y, Mahmoud A, Barghash M, Elsayed Z, Elsawi A, et al.
Bioorg Chem
. 2024 Sep;
153:107829.
PMID: 39317037
Vascular endothelial growth factor (VEGF) is a crucial key factor in breast tumorigenesis. VEGF plays an important role in angiogenesis, tumor proliferation, and metastasis. Herein, we report the design and...
6.
Hassan R, Ali I, El Kerdawy A, Abo-Elfadl M, Ghannam I
Bioorg Chem
. 2024 Aug;
152:107728.
PMID: 39178704
In the current study, a new series of benzenesulfonamides 6a-r was designed and synthesized as dual VEGFR-2 and FGFR1 kinase inhibitors with anti-cancer activity. The 4-trifluoromethyl benzenesulfonamide 6l exhibited the...
7.
Mostafa E, Azim M, ElZaher A, Elkady E, Fouad M, Ghazy F, et al.
Sci Rep
. 2024 Aug;
14(1):18741.
PMID: 39138274
Artificial neural networks (ANNs) are biologically inspired algorithms designed to simulate the way in which the human brain processes information. In sample preparation for bioanalysis, liquid-liquid extraction (LLE) represents an...
8.
Nemr M, Elshewy A, Ibrahim M, El Kerdawy A, Halim P
Bioorg Chem
. 2024 Jun;
150:107566.
PMID: 38896936
In the current study, novel pyrazolo[3,4-d]pyrimidine derivatives 5a-h were designed and synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The designed compounds demonstrated moderate to potent activity on the...
9.
Abdo Moustafa E, Abdelrasheed Allam H, Fouad M, El Kerdawy A, Nasser Eid El-Sayed N, Wagner C, et al.
Bioorg Chem
. 2024 Apr;
146:107324.
PMID: 38569322
Recently, glycogen synthase kinase-3β (GSK-3β) has been considered as a critical factor implicated in Alzheimer's disease (AD). In a previous work, a 3D pharmacophore model for GSK-3β inhibitors was created...
10.
Abdel-Sattar E, Kutkat O, El-Shiekh R, El-Ashrey M, El Kerdawy A
Chem Biodivers
. 2024 Mar;
21(4):e202301786.
PMID: 38466126
SARS-CoV-2 caused pandemic represented a major risk for the worldwide human health, animal health and economy, forcing extraordinary efforts to discover drugs for its prevention and cure. Considering the extensive...