Ahmed Amine Khamlichi
Overview
Explore the profile of Ahmed Amine Khamlichi including associated specialties, affiliations and a list of published articles.
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34
Citations
439
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Recent Articles
11.
Oudinet C, Braikia F, Dauba A, Santos J, Khamlichi A
PLoS Genet
. 2019 Feb;
15(2):e1007930.
PMID: 30779742
DNA cytosine methylation is involved in the regulation of gene expression during development and its deregulation is often associated with disease. Mammalian genomes are predominantly methylated at CpG dinucleotides. Unmethylated...
12.
Jamrog L, Chemin G, Fregona V, Coster L, Pasquet M, Oudinet C, et al.
Proc Natl Acad Sci U S A
. 2018 Sep;
115(41):10357-10362.
PMID: 30257940
is a well-known haploinsufficient tumor suppressor gene in human B-cell precursor acute lymphoblastic leukemia (B-ALL) and is involved in various chromosomal translocations that fuse a part of PAX5 with other...
13.
Khamlichi A, Feil R
Trends Genet
. 2018 Sep;
34(12):954-971.
PMID: 30217559
Different types of monoallelic gene expression are present in mammals, some of which are highly flexible, whereas others are more rigid. These include allelic exclusion at antigen receptor loci, the...
14.
Santos J, Braikia F, Oudinet C, Haddad D, Conte C, Dauba A, et al.
Sci Rep
. 2018 Jun;
8(1):9164.
PMID: 29907762
During an adaptive immune response, B cells can change their surface immunoglobulins from IgM to IgG, IgE or IgA through a process called class switch recombination (CSR). Switching is preceded...
15.
Braikia F, Oudinet C, Haddad D, Oruc Z, Orlando D, Dauba A, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(23):6092-6097.
PMID: 28533409
Class switch recombination (CSR) plays an important role in adaptive immune response by enabling mature B cells to switch from IgM expression to the expression of downstream isotypes. CSR is...
16.
Braikia F, Conte C, Moutahir M, Denizot Y, Cogne M, Khamlichi A
Mol Cell Biol
. 2015 Jul;
35(19):3370-80.
PMID: 26195822
Eukaryotic gene expression is often controlled by distant regulatory elements. In developing B lymphocytes, transcription is associated with V(D)J recombination at immunoglobulin loci. This process is regulated by remote cis-acting...
17.
Puget N, Leduc C, Oruc Z, Moutahir M, Le Bert M, Khamlichi A
Mol Cell Biol
. 2015 Apr;
35(13):2231-41.
PMID: 25896912
Developing lymphocytes somatically diversify their antigen-receptor loci through V(D)J recombination. The process is associated with allelic exclusion, which results in monoallelic expression of an antigen receptor locus. Various cis-regulatory elements...
18.
Puget N, Hirasawa R, Hu N, Laviolette-Malirat N, Feil R, Khamlichi A
Mol Cell Biol
. 2014 Nov;
35(3):529-43.
PMID: 25403489
The assembly of antigen receptor loci requires a developmentally regulated and lineage-specific recombination between variable (V), diversity (D), and joining (J) segments through V(D)J recombination. The process is regulated by...
19.
Braikia F, Chemin G, Moutahir M, Khamlichi A
Immunol Lett
. 2014 Aug;
162(1 Pt A):119-23.
PMID: 25128366
B and T lymphocytes have the unique capacity to somatically rearrange their antigen receptor loci through V(D)J recombination. D-JH and VH-DJH recombination events are usually visualized by semi-quantitative PCR followed...
20.
Leduc C, Chemin G, Puget N, Sawan C, Moutahir M, Herceg Z, et al.
Cell Cycle
. 2014 Mar;
13(10):1583-9.
PMID: 24675885
The transformation/transcription domain-associated protein (TRRAP) is a common component of many histone acetyltransferase (HAT) complexes. Targeted-deletion of the Trrap gene led to early embryonic lethality and revealed a critical function...