Agustin Hidalgo-Gutierrez
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Explore the profile of Agustin Hidalgo-Gutierrez including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Pesini A, Barriocanal-Casado E, Monzio Compagnoni G, Hidalgo-Gutierrez A, Yanez G, Bakkali M, et al.
Free Radic Biol Med
. 2025 Jan;
229:441-457.
PMID: 39788391
Coenzyme Q (CoQ) is a critical component of the mitochondrial respiratory chain. CoQ deficiencies cause a variety of clinical syndromes, often involving encephalopathies. The heterogeneity of clinical manifestations implies different...
2.
Hidalgo-Gutierrez A, Shintaku J, Ramon J, Barriocanal-Casado E, Pesini A, Saneto R, et al.
Ann Neurol
. 2024 Sep;
96(6):1209-1224.
PMID: 39230499
Objective: Mitochondrial DNA (mtDNA) depletion/deletions syndrome (MDDS) comprises a group of diseases caused by primary autosomal defects of mtDNA maintenance. Our objective was to study the etiology of MDDS in...
3.
Diaz-Casado M, Gonzalez-Garcia P, Lopez-Herrador S, Hidalgo-Gutierrez A, Jimenez-Sanchez L, Barriocanal-Casado E, et al.
Biochim Biophys Acta Mol Basis Dis
. 2024 Jun;
1870(7):167283.
PMID: 38851305
Obesity represents a significant health challenge, intricately linked to conditions such as type II diabetes, metabolic syndrome, and hepatic steatosis. Several existing obesity treatments exhibit limited efficacy, undesirable side effects...
4.
Aragon-Vela J, Casuso R, Aparisi A, Plaza-Diaz J, Rueda-Robles A, Hidalgo-Gutierrez A, et al.
J Physiol
. 2024 Apr;
602(21):5631-5641.
PMID: 38630964
In eukaryotic cells, aerobic energy is produced by mitochondria through oxygen uptake. However, little is known about the early mitochondrial responses to moderate hypobaric hypoxia (MHH) in highly metabolic active...
5.
Florido J, Martinez-Ruiz L, Rodriguez-Santana C, Lopez-Rodriguez A, Hidalgo-Gutierrez A, Cottet-Rousselle C, et al.
J Pineal Res
. 2022 Aug;
73(3):e12824.
PMID: 35986493
The oncostatic effects of melatonin correlate with increased reactive oxygen species (ROS) levels, but how melatonin induces this ROS generation is unknown. In the present study, we aimed to elucidate...
6.
Gonzalez-Garcia P, Diaz-Casado M, Hidalgo-Gutierrez A, Jimenez-Sanchez L, Bakkali M, Barriocanal-Casado E, et al.
Redox Biol
. 2022 Jul;
55:102403.
PMID: 35863266
Defects in Coenzyme Q (CoQ) metabolism have been associated with primary mitochondrial disorders, neurodegenerative diseases and metabolic conditions. The consequences of CoQ deficiency have not been fully addressed, and effective...
7.
Pesini A, Hidalgo-Gutierrez A, Quinzii C
Antioxidants (Basel)
. 2022 Apr;
11(4).
PMID: 35453349
Coenzyme Q (CoQ) is a conserved polyprenylated lipid composed of a redox-active benzoquinone ring and a long polyisoprenyl tail that serves as a membrane anchor. CoQ biosynthesis involves multiple steps,...
8.
Gonzalez-Garcia P, Barriocanal-Casado E, Diaz-Casado M, Lopez-Herrador S, Hidalgo-Gutierrez A, Lopez L
Antioxidants (Basel)
. 2021 Nov;
10(11).
PMID: 34829558
Coenzyme Q (CoQ) is a vital lipophilic molecule that is endogenously synthesized in the mitochondria of each cell. The CoQ biosynthetic pathway is complex and not completely characterized, and it...
9.
Hidalgo-Gutierrez A, Barriocanal-Casado E, Diaz-Casado M, Gonzalez-Garcia P, Chiozzi R, Acuna-Castroviejo D, et al.
Biomedicines
. 2021 Oct;
9(10).
PMID: 34680574
Primary mitochondrial diseases are caused by mutations in mitochondrial or nuclear genes, leading to the abnormal function of specific mitochondrial pathways. Mitochondrial dysfunction is also a secondary event in more...
10.
Hidalgo-Gutierrez A, Gonzalez-Garcia P, Diaz-Casado M, Barriocanal-Casado E, Lopez-Herrador S, Quinzii C, et al.
Antioxidants (Basel)
. 2021 Apr;
10(4).
PMID: 33810539
Coenzyme Q10 (CoQ) is classically viewed as an important endogenous antioxidant and key component of the mitochondrial respiratory chain. For this second function, CoQ molecules seem to be dynamically segmented...