Agnieszka Gembarska
Overview
Explore the profile of Agnieszka Gembarska including associated specialties, affiliations and a list of published articles.
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6
Citations
356
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Recent Articles
1.
Chapeau E, Gembarska A, Durand E, Mandon E, Estadieu C, Romanet V, et al.
Proc Natl Acad Sci U S A
. 2017 Mar;
114(12):3151-3156.
PMID: 28265066
Inhibitors of double minute 2 protein (MDM2)-tumor protein 53 (TP53) interaction are predicted to be effective in tumors in which the gene is wild type, by preventing TP53 protein degradation....
2.
Singh R, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, et al.
Blood
. 2013 May;
121(26):5158-66.
PMID: 23667053
Hypoxia is a prominent feature in the maintenance of hematopoietic stem cell (HSC) quiescence and multipotency. Hypoxia-inducible factor (HIF) prolyl hydroxylase domain proteins (PHDs) serve as oxygen sensors and may...
3.
Gembarska A, Luciani F, Fedele C, Russell E, Dewaele M, Villar S, et al.
Nat Med
. 2012 Jul;
18(8):1239-47.
PMID: 22820643
The inactivation of the p53 tumor suppressor pathway, which often occurs through mutations in TP53 (encoding tumor protein 53) is a common step in human cancer. However, in melanoma-a highly...
4.
De Clercq S, Gembarska A, Denecker G, Maetens M, Naessens M, Haigh K, et al.
Mol Cell Biol
. 2010 Sep;
30(22):5394-405.
PMID: 20855528
Mdm2 and Mdm4 are critical negative regulators of p53. A large body of evidence indicates that elevated expression of either Mdm2 or Mdm4 may favor tumor formation by inhibiting p53...
5.
Nyabi O, Naessens M, Haigh K, Gembarska A, Goossens S, Maetens M, et al.
Nucleic Acids Res
. 2009 Mar;
37(7):e55.
PMID: 19279185
The ability to rapidly and efficiently generate reliable Cre/loxP conditional transgenic mice would greatly complement global high-throughput gene targeting initiatives aimed at identifying gene function in the mouse. We report...
6.
Jurek A, Amagasaki K, Gembarska A, Heldin C, Lennartsson J
J Biol Chem
. 2008 Dec;
284(7):4626-34.
PMID: 19106095
MAPK phosphatases (MKPs) are dual specificity phosphatases that dephosphorylate and thereby inactivate MAPKs. In the present study, we provide evidence that platelet-derived growth factor BB (PDGF-BB) regulates MKP3 (DUSP6), which...