Agata Steenackers
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Explore the profile of Agata Steenackers including associated specialties, affiliations and a list of published articles.
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20
Citations
349
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Recent Articles
11.
Steenackers A, Olivier-Van Stichelen S, Baldini S, Dehennaut V, Toillon R, Le Bourhis X, et al.
Front Endocrinol (Lausanne)
. 2016 Jun;
7:46.
PMID: 27252680
The post-translational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is regulated by a unique couple of enzymes. O-GlcNAc transferase (OGT) transfers the GlcNAc residue from UDP-GlcNAc, the final product of...
12.
Vercoutter-Edouart A, El Yazidi-Belkoura I, Guinez C, Baldini S, Leturcq M, Mortuaire M, et al.
Proteomics
. 2014 Nov;
15(5-6):1039-50.
PMID: 25429863
O-GlcNAcylation (O-linked beta-N-acetylglucosaminylation) is a widespread PTM confined within the nuclear, the cytosolic, and the mitochondrial compartments of eukaryotes. Recently, O-GlcNAcylation has been also detected in the close vicinity of...
13.
Julien S, Bobowski M, Steenackers A, Le Bourhis X, Delannoy P
Cells
. 2014 Apr;
2(4):751-67.
PMID: 24709879
Gangliosides, the glycosphingolipids carrying one or several sialic acid residues, are located on the outer leaflet of the plasma membrane in glycolipid-enriched microdomains, where they interact with molecules of signal...
14.
Hottin A, Wright D, Steenackers A, Delannoy P, Dubar F, Biot C, et al.
Chemistry
. 2013 Jun;
19(29):9526-33.
PMID: 23740878
Enhanced metabolism of fucose through fucosidase overexpression is a signature of some cancer types, thus suggesting that fucosidase-targetted ligands could play the role of drug-delivery vectors. Herein, we describe the...
15.
Martinez P, Vergoten G, Colomb F, Bobowski M, Steenackers A, Carpentier M, et al.
Clin Exp Metastasis
. 2013 Jun;
30(7):919-31.
PMID: 23739843
Distant metastasis account for about 90 % of cancer associated deaths, and yet the oncology field is cruelly lacking tools to accurately predict and/or prevent metastasis. Distant metastasis occurs when...
16.
Bobowski M, Vincent A, Steenackers A, Colomb F, Van Seuningen I, Julien S, et al.
PLoS One
. 2013 Apr;
8(4):e62559.
PMID: 23626833
Recent data have underlined a possible role of G(D3) synthase (GD3S) and complex gangliosides in Estrogen Receptor (ER) negative breast cancer progression. Here, we describe the main transcript of the...
17.
Steenackers A, Vanbeselaere J, Cazet A, Bobowski M, Rombouts Y, Colomb F, et al.
Molecules
. 2012 Aug;
17(8):9559-72.
PMID: 22885356
Glycosphingolipids from the ganglio-series are usually classified in four series according to the presence of 0 to 3 sialic acid residues linked to lactosylceramide. The transfer of sialic acid is...
18.
Hottin A, Dubar F, Steenackers A, Delannoy P, Biot C, Behr J
Org Biomol Chem
. 2012 Jun;
10(29):5592-7.
PMID: 22717621
We prepared a series of new iminosugar-ferrocene hybrids displaying potent inhibition of fucosidase (bovine kidney) and inactivation of MDA-MB-231 breast cancer cells proliferation at low micromolar concentrations. The synthetic route...
19.
Colomb F, Krzewinski-Recchi M, El Machhour F, Mensier E, Jaillard S, Steenackers A, et al.
Biochimie
. 2012 Jun;
94(9):2045-53.
PMID: 22691873
Bronchial mucins from severely infected patients suffering from lung diseases such as chronic bronchitis or cystic fibrosis exhibit increased amounts of sialyl-Lewis(x) (NeuAcα2-3Galβ1-4[Fucα1-3]GlcNAc-R, sLe(x)) glycan structures. In cystic fibrosis, sLe(x)...
20.
Cazet A, Bobowski M, Rombouts Y, Lefebvre J, Steenackers A, Popa I, et al.
Glycobiology
. 2012 Feb;
22(6):806-16.
PMID: 22301273
We have recently established and characterized cellular clones deriving from MDA-MB-231 breast cancer cells that express the human G(D3) synthase (GD3S), the enzyme that controls the biosynthesis of b- and...