Adva Mechaly
Overview
Explore the profile of Adva Mechaly including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
737
Followers
0
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Recent Articles
1.
Rosner A, Steiner M, Melamed S, Politi B, Vitner E, Tamir H, et al.
Arch Toxicol
. 2022 May;
96(8):2329-2339.
PMID: 35577986
BriLife, a vector-based vaccine that utilizes the recombinant vesicular stomatitis virus (VSV) platform to express and present the spike antigen of SARS-CoV-2, is undergoing testing in a phase 2 clinical...
2.
Mechaly A, Diamant E, Alcalay R, Ben David A, Dor E, Torgeman A, et al.
Antibodies (Basel)
. 2022 Mar;
11(1).
PMID: 35323195
Botulinum neurotoxin type E (BoNT/E), the fastest acting toxin of all BoNTs, cleaves the 25 kDa synaptosomal-associated protein (SNAP-25) in motor neurons, leading to flaccid paralysis. The specific detection and...
3.
Fisher M, Manor A, Abramovitch H, Fatelevich E, Afrimov Y, Bilinsky G, et al.
Anal Chem
. 2022 Mar;
94(10):4380-4389.
PMID: 35230823
A multi-component microarray, applying a novel analysis algorithm, was developed for quantitative evaluation of the SARS-CoV-2 vaccines' immunogenicity. The array enables simultaneous quantitation of IgG, IgM, and IgA, specific to...
4.
Yahalom-Ronen Y, Erez N, Fisher M, Tamir H, Politi B, Achdout H, et al.
Vaccines (Basel)
. 2022 Feb;
10(2).
PMID: 35214749
The emergence of rapidly spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a major challenge to the ability of vaccines and therapeutic antibodies to provide immunity. These...
5.
Diamant E, Torgeman A, Epstein E, Mechaly A, Ben David A, Levin L, et al.
ALTEX
. 2021 Nov;
39(1):113-122.
PMID: 34798660
The pharmacopeia mouse neutralization assay (PMNA) is the standard method for determining the potency of pharmaceutical botulinum antitoxins. However, a PMNA requires a large number of mice, and, thus, an...
6.
Fisher M, Levy H, Fatelevich E, Afrimov Y, Ben-Shmuel A, Rosenfeld R, et al.
Microbiol Spectr
. 2021 Oct;
9(2):e0087021.
PMID: 34612689
The first case of SARS-CoV-2 was discovered in Israel in late February 2020. Three major outbreaks followed, resulting in over 800,000 cases and over 6,000 deaths by April 2021. Our...
7.
Noy-Porat T, Alcalay R, Mechaly A, Peretz E, Makdasi E, Rosenfeld R, et al.
STAR Protoc
. 2021 Sep;
2(4):100836.
PMID: 34568849
This protocol describes the use of a biolayer interferometry platform for assessing antibody-antigen interactions. The protocol focuses on affinity determination and epitope binning, although the system can be utilized for...
8.
Makdasi E, Zvi A, Alcalay R, Noy-Porat T, Peretz E, Mechaly A, et al.
Cell Rep
. 2021 Aug;
36(10):109679.
PMID: 34464610
A wide range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing monoclonal antibodies (mAbs) have been reported, most of which target the spike glycoprotein. Therapeutic implementation of these antibodies...
9.
Barlev-Gross M, Weiss S, Paran N, Yahalom-Ronen Y, Israeli O, Nemet I, et al.
J Infect Dis
. 2021 Aug;
224(4):616-619.
PMID: 34398244
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants may influence the effectiveness of existing laboratory diagnostics. In the current study we determined whether the British (20I/501Y.V1) and South African...
10.
Noy-Porat T, Mechaly A, Levy Y, Makdasi E, Alcalay R, Gur D, et al.
iScience
. 2021 May;
24(5):102479.
PMID: 33937725
Neutralizing antibodies represent a valuable therapeutic approach to countermeasure the current COVID-19 pandemic. Emergence of SARS-CoV-2 variants emphasizes the notion that antibody treatments need to rely on highly neutralizing monoclonal...