Adrian Schmalen
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Explore the profile of Adrian Schmalen including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
57
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Recent Articles
1.
Fleischer A, Amann B, von Toerne C, Degroote R, Schmalen A, Weisser T, et al.
Biomolecules
. 2025 Feb;
15(2).
PMID: 40001591
Retinal Müller glial cells (RMG) play a crucial role in retinal neuroinflammation, including autoimmune uveitis. Increasing evidence supports their function as active modulators of immune responses and potential atypical antigen-presenting...
2.
Degroote R, Schmalen A, Renner S, Wolf E, Hauck S, Deeg C
Proteomics
. 2024 Aug;
24(20):e2300591.
PMID: 39126128
INS transgenic pigs represent a model for mutant insulin gene-induced diabetes of youth, with impaired insulin secretion and beta cell loss, leading to elevated fasting blood glucose levels. A key...
3.
Degroote R, Schmalen A, Hauck S, Deeg C
Biomedicines
. 2024 Jan;
12(1).
PMID: 38275380
The perception of circulating granulocytes as cells with a predetermined immune response mainly triggered by pathogens is evolving, recognizing their functional heterogeneity and adaptability, particularly within the neutrophil subset. The...
4.
Schmalen A, Kammerl I, Meiners S, Noessner E, Deeg C, Hauck S
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759700
The majority of peptides presented by MHC class I result from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation....
5.
Chen J, Wang X, Schmalen A, Haines S, Wolff M, Ma H, et al.
Eur Respir J
. 2023 Jun;
62(2).
PMID: 37385655
Background: Virus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8 T-cells by viral epitopes presented on major histocompatibility complex (MHC) class I molecules...
6.
Schmalen A, Lorenz L, Grosche A, Pauly D, Deeg C, Hauck S
Front Pharmacol
. 2021 Nov;
12:771571.
PMID: 34776983
Müller cells are the main macroglial cells of the retina exerting a wealth of functions to maintain retinal homoeostasis. Upon pathological changes in the retina, they become gliotic with both...
7.
Lorenz L, Hirmer S, Schmalen A, Hauck S, Deeg C
Cells
. 2021 Apr;
10(3).
PMID: 33806940
Retinal Müller glial cells (RMG) are involved in virtually every retinal disease; however, the role of these glial cells in neuroinflammation is still poorly understood. Since cell surface proteins play...
8.
Schmalen A, Karius-Fischer J, Rauch P, Setz C, Korn K, Henklein P, et al.
Viruses
. 2018 Dec;
10(12).
PMID: 30545091
As part of the Pr55 polyprotein, p6 fulfills an essential role in the late steps of the replication cycle. However, almost nothing is known about the functions of the mature...
9.
Hahn F, Schmalen A, Setz C, Friedrich M, Schlosser S, Kolle J, et al.
PLoS One
. 2017 Apr;
12(4):e0174254.
PMID: 28388673
There is a significantly higher risk for type II diabetes in HIV-1 carriers, albeit the molecular mechanism for this HIV-related pathology remains enigmatic. The 52 amino acid HIV-1 p6 Gag...