Silke Meiners
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Explore the profile of Silke Meiners including associated specialties, affiliations and a list of published articles.
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92
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2381
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Recent Articles
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Eibach Y, Kreher S, Poetsch M, Kho A, Gaertner U, Clemen C, et al.
Sci Adv
. 2025 Jan;
11(4):eado3852.
PMID: 39841822
Protein homeostasis is crucial for maintaining cardiomyocyte (CM) function. Disruption of proteostasis results in accumulation of protein aggregates causing cardiac pathologies such as hypertrophy, dilated cardiomyopathy (DCM), and heart failure....
3.
Risha M, Reddy K, Nemani S, Jakwerth C, Schmidt-Weber C, Bahmer T, et al.
Allergy
. 2024 Nov;
79(12):3385-3400.
PMID: 39513674
Background: Humans are subjected to various environmental stressors (bacteria, viruses, pollution) throughout life. As such, an inherent relationship exists between the effect of these exposures with age. The impact of...
4.
Meiners S, Reynaert N, Matthaiou A, Rajesh R, Ahmed E, Guillamat-Prats R, et al.
Breathe (Sheff)
. 2024 May;
20(1):230183.
PMID: 38746906
The Translational Science Working Group at the European Respiratory Society (ERS) aims to bridge the gap between basic and clinical science by providing a platform where scientists, clinicians and experts...
5.
Schmalen A, Kammerl I, Meiners S, Noessner E, Deeg C, Hauck S
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759700
The majority of peptides presented by MHC class I result from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation....
6.
Farr A, Cuevas Ocana S, Gille T, Pinnock H, Bonsignore M, Roche N, et al.
Breathe (Sheff)
. 2023 Jul;
19(2):230107.
PMID: 37492348
https://bit.ly/46ghP4g.
7.
Chen J, Wang X, Schmalen A, Haines S, Wolff M, Ma H, et al.
Eur Respir J
. 2023 Jun;
62(2).
PMID: 37385655
Background: Virus infections drive COPD exacerbations and progression. Antiviral immunity centres on the activation of virus-specific CD8 T-cells by viral epitopes presented on major histocompatibility complex (MHC) class I molecules...
8.
Javitt A, Shmueli M, Kramer M, Kolodziejczyk A, Cohen I, Radomir L, et al.
Nat Cancer
. 2023 May;
4(5):629-647.
PMID: 37217651
Immunotherapy revolutionized treatment options in cancer, yet the mechanisms underlying resistance in many patients remain poorly understood. Cellular proteasomes have been implicated in modulating antitumor immunity by regulating antigen processing,...
9.
Wang X, Zhang H, Wang Y, Bramasole L, Guo K, Mourtada F, et al.
EMBO J
. 2023 Mar;
42(8):e110597.
PMID: 36912165
The immunoproteasome is a specialized type of proteasome involved in MHC class I antigen presentation, antiviral adaptive immunity, autoimmunity, and is also part of a broader response to stress. Whether...
10.
Zambusi A, Novoselc K, Hutten S, Kalpazidou S, Koupourtidou C, Schieweck R, et al.
Nat Neurosci
. 2022 Nov;
25(12):1608-1625.
PMID: 36424432
Decreasing the activation of pathology-activated microglia is crucial to prevent chronic inflammation and tissue scarring. In this study, we used a stab wound injury model in zebrafish and identified an...