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Adrian L Watson

Explore the profile of Adrian L Watson including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 289
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Recent Articles
1.
Popa I, Solgadi A, Pin D, Watson A, Haftek M, Portoukalian J
Metabolites . 2021 Dec; 11(12). PMID: 34940561
Golden Retrievers may suffer from -related inherited ichthyosis. Our study shows that in the stratum corneum (SC) of ichthyotic dogs, linoleic acid (LA) is also present in the form of...
2.
Wu X, Mandigers P, Watson A, van den Ingh T, Leegwater P, Fieten H
J Vet Intern Med . 2019 Jun; 33(4):1646-1652. PMID: 31254371
Background: Hepatic copper accumulation causes chronic hepatitis in dogs. Mutations in the copper transporters ATP7A and ATP7B were, respectively, associated with attenuation and enhancement of hepatic copper concentrations in Labrador...
3.
Popa I, Watson A, Solgadi A, Butowski C, Allaway D, Portoukalian J
Arch Dermatol Res . 2018 Jul; 310(7):579-589. PMID: 29995261
Few studies have investigated the influence of increased amounts of dietary linoleic acid on the epidermal lipid biochemistry and TEWL in healthy subject. The influence of dietary linoleic acid on...
4.
Dirksen K, Spee B, Penning L, van den Ingh T, Burgener I, Watson A, et al.
PLoS One . 2017 May; 12(5):e0176826. PMID: 28459846
Copper is an essential trace element, but can become toxic when present in abundance. The severe effects of copper-metabolism imbalance are illustrated by the inherited disorders Wilson disease and Menkes...
5.
Fieten H, Gill Y, Martin A, Concilli M, Dirksen K, van Steenbeek F, et al.
Dis Model Mech . 2016 Jan; 9(1):25-38. PMID: 26747866
The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases caused by mutations in the genes coding for the copper transporters ATP7A and ATP7B. Menkes disease, involving...
6.
Fieten H, Biourge V, Watson A, Leegwater P, van den Ingh T, Rothuizen J
Vet J . 2014 Jan; 199(3):429-33. PMID: 24439471
Canine hereditary copper-associated hepatitis is characterized by gradual hepatic copper accumulation eventually leading to liver cirrhosis. Therapy is aimed at creating a negative copper balance with metal chelators, of which...
7.
Fieten H, Dirksen K, van den Ingh T, Winter E, Watson A, Leegwater P, et al.
Vet J . 2013 Feb; 196(3):522-7. PMID: 23375251
d-penicillamine is effectively used in the lifelong treatment of copper toxicosis in Bedlington terriers and Wilson's disease in humans. A complex form of copper-associated hepatitis has recently been characterized in...
8.
Hutchinson D, Sutherland-Smith J, Watson A, Freeman L
Am J Vet Res . 2012 Oct; 73(11):1794-800. PMID: 23106466
Objective: To evaluate clinically applicable methods of assessing lean body mass in dogs and compare muscle mass and inflammatory markers in healthy young and old dogs. Animals: 9 healthy young...
9.
Fieten H, Leegwater P, Watson A, Rothuizen J
Mamm Genome . 2011 Dec; 23(1-2):62-75. PMID: 22147205
Hereditary forms of copper toxicosis exist in man and dogs. In man, Wilson's disease is the best studied disorder of copper overload, resulting from mutations in the gene coding for...
10.
Watson A, Fray T, Bailey J, Baker C, Beyer S, Markwell P
Exp Dermatol . 2005 Dec; 15(1):74-81. PMID: 16364034
Epidermal barrier function is a critical attribute of mammalian skin. The barrier is responsible for preventing skin-associated pathologies through controlling egress of water and preventing ingress of environmental agents. Maintaining...