Adrian L Sanborn
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Explore the profile of Adrian L Sanborn including associated specialties, affiliations and a list of published articles.
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11
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7071
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Recent Articles
1.
Viana M, Chen J, Knijnenburg T, Vasan R, Yan C, Arakaki J, et al.
Nature
. 2023 Jan;
613(7943):345-354.
PMID: 36599983
Understanding how a subset of expressed genes dictates cellular phenotype is a considerable challenge owing to the large numbers of molecules involved, their combinatorics and the plethora of cellular behaviours...
2.
Sanborn A, Yeh B, Feigerle J, Hao C, Townshend R, Aiden E, et al.
Elife
. 2021 Apr;
10.
PMID: 33904398
Gene activator proteins comprise distinct DNA-binding and transcriptional activation domains (ADs). Because few ADs have been described, we tested domains tiling all yeast transcription factors for activation in vivo and...
3.
Huang W, Manglik A, Venkatakrishnan A, Laeremans T, Feinberg E, Sanborn A, et al.
Nature
. 2020 Jul;
584(7820):E16.
PMID: 32724208
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
4.
Rowley M, Poulet A, Nichols M, Bixler B, Sanborn A, Brouhard E, et al.
Genome Res
. 2020 Mar;
30(3):447-458.
PMID: 32127418
Chromatin loops are a major component of 3D nuclear organization, visually apparent as intense point-to-point interactions in Hi-C maps. Identification of these loops is a critical part of most Hi-C...
5.
Vian L, Pekowska A, Rao S, Kieffer-Kwon K, Jung S, Baranello L, et al.
Cell
. 2018 Sep;
175(1):292-294.
PMID: 30241609
No abstract available.
6.
Vian L, Pekowska A, Rao S, Kieffer-Kwon K, Jung S, Baranello L, et al.
Cell
. 2018 May;
173(5):1165-1178.e20.
PMID: 29706548
Cohesin extrusion is thought to play a central role in establishing the architecture of mammalian genomes. However, extrusion has not been visualized in vivo, and thus, its functional impact and...
7.
Rao S, Huang S, St Hilaire B, Engreitz J, Perez E, Kieffer-Kwon K, et al.
Cell
. 2017 Oct;
171(2):305-320.e24.
PMID: 28985562
The human genome folds to create thousands of intervals, called "contact domains," that exhibit enhanced contact frequency within themselves. "Loop domains" form because of tethering between two loci-almost always bound...
8.
Darrow E, Huntley M, Dudchenko O, Stamenova E, Durand N, Sun Z, et al.
Proc Natl Acad Sci U S A
. 2016 Jul;
113(31):E4504-12.
PMID: 27432957
During interphase, the inactive X chromosome (Xi) is largely transcriptionally silent and adopts an unusual 3D configuration known as the "Barr body." Despite the importance of X chromosome inactivation, little...
9.
Sanborn A, Rao S, Huang S, Durand N, Huntley M, Jewett A, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(47):E6456-65.
PMID: 26499245
We recently used in situ Hi-C to create kilobase-resolution 3D maps of mammalian genomes. Here, we combine these maps with new Hi-C, microscopy, and genome-editing experiments to study the physical...
10.
Huang W, Manglik A, Venkatakrishnan A, Laeremans T, Feinberg E, Sanborn A, et al.
Nature
. 2015 Aug;
524(7565):315-21.
PMID: 26245379
Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR activation, here we report a...